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February 14, 2020
Susan Rice is interviewed by a16z General Partner Kathryn Haun. Rice, the former National Security Advisor and U.S. Ambassador to the U.N., learned early in life the importance of toughness in the face of adversity. In this discussion, she shares many more lessons from her personal life and career, including how to stay calm during crises, not letting others define you, and work-life balance.
February 7, 2020
CAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias that we believe it may actually be a cure. But this isn't just one new medicine, it's an entirely new therapeutic tool—and a total paradigm shift from most traditional medicines we've seen before.
February 4, 2020
with @francescagino and @omnivorousread In this episode of the a16z Podcast, Harvard Business School Professor Francesca Gino, a social scientist who studies organizations, breaks down what makes rebels different in how they tend to see and do things—whether that’s cooking, flying planes, or holding board meetings—and what we can all learn from “rebel talent” to make our organizations more productive and innovative.
January 30, 2020
with @heyjudka @smc90 This episode of 16 Minutes on the news from a16z (cross-posted here as well) covers what we know and what we don't know about the recent coronavirus outbreak 2019-nCoV. Topics covered include the what, when, how -- and where genomics comes in.
January 27, 2020
The idea of "1000 true fans" argued that to be a successful creator, you don’t need millions of customers or clients, as long as you also have a direct relationship with those fans. But how is media changing today as a result, and what nuances do people often miss about the concept? And why are we apparently surrendering our attention (whether to TV, books, or whatever) for only $3 an hour?!
January 27, 2020
with @cjgbest @robertcottrell @andrewchen @smc90 A new ecosystem is forming around the direct relationship between consumers, content creators, and the tools and business models to facilitate all that. We're not just seeing this phenomenon in newsletters and podcasting, but also in people setting up e-commerce shops, video streaming, and more. Are the stars and the incentives finally aligned?
January 19, 2020
Chris Dixon, a16z General Partner, is interviewed by Jonah Peretti, founder and CEO of Buzzfeed. They discuss all things internet, including how innovation comes about, the ways disparate trends collide, and more.
January 16, 2020
AI can do a lot of specific tasks as well as, or even better than, humans can — for example, it can more accurately classify images, more efficiently process mail, and more logically manipulate a Go board. While we have made a lot of advances in task-specific AI, how far are we from artificial general intelligence (AGI), that is AI that matches general human intelligence and capabilities? In this podcast, a16z operating partner Frank Chen interviews Stuart Russell, Founder of the Center for Human-Compatible Artificial Intelligence (CHAI) at UC Berkeley. They outline the conceptual breakthroughs, like natural language understanding, still required for AGI. But more importantly, they explain how and why we should design AI systems to ensure that we can control AI, and eventually AGI, when it’s smarter than we are. The conversation starts by explaining what Hollywood's Skynet gets wrong and ends with why AI is better as "the perfect Butler, than the genie in the lamp."
January 14, 2020
The federal agency known as the FDA, or the Food and Drug Administration, was born over 100 years ago—at the turn of the industrial revolution, in a time of enormous upheaval and change, and rapidly emerging technology. The same could be said to be just as true today. This wide-ranging conversation between Principal Commissioner of the FDA Amy Abernethy and Vijay Pande, GP on the Bio Fund at a16z, discusses how the agency is evolving to keep pace with the scientific breakthroughs like CRISPR and AI, while staying true to its core mission of assessing safety and effectiveness for consumers in the world of food and medicine.
January 11, 2020
with @vasnarasimhan @jorgecondebio @vijaypande @smc90 How does the world’s largest producer of medicines in terms of volume balance the science and  the business of innovation, from R&D to go to market to talent and more?
January 6, 2020
with @jorgecondebio and @smc90 A look-back and look-forward on the topic of personal genomics, given recent and past retrospective and prospective pieces in the media on the topics of DNA sequencing, personalized medicine, criminal investigations, genetic privacy and large datasets, multiomics, and more.
January 2, 2020
Kevin Kelly interviews Marc Andreessen at our most recent innovation Summit; they discuss the evolution of technology, key trends, and why they're the most optimistic people in the room.
December 23, 2019
with @mikeleiter @katie_haun What does the Committee on Foreign Investment in the U.S. (CFIUS) and updates to the Foreign Investment Risk Review Modernization Act (FIRRMA) mean for founders taking investments from or doing joint ventures with foreign entities or just doing business globally in general? What does and doesn't CFIUS cover, and how might one structure partnerships strategically as a result?
December 19, 2019
A bold proposal: You go to college for free, then pay back the school after graduation—but only if you get a job in your field of study and make a high enough salary to afford it. It's called an income share agreement, and Austen Allred, the CEO and cofounder of Lambda School, thinks it's the future of education.
December 17, 2019
with @shondarhimes @pmarca The creator of hit shows like Grey's Anatomy, Scandal, and others, writer and executive producer Shonda Rhimes shares lessons she's learned about pitching ideas, storytelling, leadership, and scaling a business across mediums.
December 17, 2019
with @pmarca and @mjr2 In this special guest hosted episode -- cross-posted from the new show Starting Greatness (featuring interviews with startup builders before they were successful, hosted by Mike Maples jr) -- Marc Andreessen shares some rare, behind-the-scenes details of his story from 0 to 1 -- from the University of Illinois and Mosaic to Netscape.
December 11, 2019
with @stacey_cunning barrymccarthy @smc90 Another route to the public markets is the direct listing, recently reinvented for tech companies (with Spotify and Slack so far). This episode of the a16z Podcast brings together two experts from the frontlines -- the architect of the direct listings in their current form, the CFO of Spotify; and president of the NYSE, where they were listed -- in conversation with Sonal Chokshi to share more about the what, the how, and the why from an insider perspective. What does it, did it take?
December 7, 2019
How do you build, set, shape, fix, change, culture? Sharing practical advice while drawing on examples of culture as code from a thousand years ago to today, as shared in his new book What You Do Is Who You Are, Horowitz shares the power of song and story. Including even violent, "shocking" ones that reset cultures, because they make you ask, WHY?!
December 3, 2019
The world's largest shopping days (Black Friday, Singles Day in China, Prime Day online, and so on) means shipping lots and lots of boxes, via big-box retailers and container ships -- but that's not the only reason we're re-running this episode of the a16z Podcast from 2017 with The Box author Marc Levinson. It's because we love logistics and infrastructure, and is really about how global innovation happens... through all sorts of invisible details.
November 28, 2019
For most of us, nurses are essentially the face of the healthcare system. In this episode, we take a look at the role of that unsung hero of healthcare, the nurse, from an industry level.
November 27, 2019
Many believe that podcasts -- authentic, intimate -- are organic conversations without editing. But most of the work often happens before and after the conversation itself, in everything from the programming to the editing. In this special 500th (!) episode of the a16z Podcast, editor-in-chief and showrunner Sonal Chokshi (in conversation with a16z general partner Connie Chan) shares answers to FAQs about the how, what, and why of the a16z Podcast, and broader editorial operation. They also take us behind the scenes to reveal some unexpected moments and lessons learned along the way, positions on tics and swear-words, failed experiments, and new directions. And where is podcasting going?
November 20, 2019
Many technical founders believe that great products and ideas sell themselves, without any extra effort or marketing. But in reality, they often need public relations (PR). The irony is, most of the work involved in PR is actually invisible to the public. So how does such brand-building really work? In this 10-year anniversary episode of the a16z Podcast, a16z operating partner Margit Wennmachers shares the case study of her work at The Outcast Agency (which she co-founded) and of building the a16z brand, where she heads marketing -- answering some FAQs about how things work, and even revealing some details behind the scenes of popular op-eds and stories about a16z.
November 2, 2019
From Fortnite to Untitled Goose Game, next-generation video games are unlike anything we've seen before. These are the tech trends turning gaming into a massive, culture-defining phenomenon.
October 24, 2019
Consumer software may have adopted and incorporated AI ahead of enterprise software, where the data is more proprietary, and the market is a few thousand companies not hundreds of millions of smartphone users. But recently AI has found its way into B2B, and it is rapidly transforming how we work and the software we use, across all industries and organizational functions.
October 21, 2019
Today, despite the critical importance of open source to software, it’s still seen by some as blasphemous to make money as an open source business. In this podcast, Armon Dadgar, Cofounder and CTO of HashiCorp; Ali Ghodsi, CEO of Databricks; and a16z General Partner Peter Levine explain why it's necessary to turn some open source projects into businesses.
October 15, 2019
with @fredbenenson @jenny8lee and @smc90 A whole new set of emojis are about to hit people's phone within a month, but that's not the only reason we're re-running this popular (and defining!) episode of the a16z Podcast from 2015. It's an evergreen classic, that is really about how innovation works -- from the politics and economics of creativity, to the design and governance of social communication systems, and much more...
October 4, 2019
It used to be that the only way for humanity to grow — and progress — was through destroying the environment. But is this interplay between human growth vs. environment really a zero-sum game? Even if it were true in history, is it true today? If capitalism is not responsible for environmental degradation, than who or what is? And where does (and doesn’t) technology come in? @pmarca and @smc90 interview MIT economist @amcafee about all this and more, given his new book, More from Less: The Surprising Story of How We Learned to Prosper Using Fewer Resources — and What Happens Next.
October 4, 2019
It used to be that the only way for humanity to grow — and progress — was through destroying the environment. But is this interplay between human growth vs. environment really a zero-sum game? Even if it were true in history, is it true today? If capitalism is not responsible for environmental degradation, than who or what is? And where does (and doesn’t) technology come in? We interview MIT economist Andrew McAfee about all this and more, given his new book, More from Less: The Surprising Story of How We Learned to Prosper Using Fewer Resources — and What Happens Next.
September 30, 2019
News and trends covered this week include: * Amazon's move into care delivery, initially for employees, what it means for incumbents and startups, the future of healthcare -- with @julesyoo @jorgecondebio * Oculus Connect 6, Facebook's annual developer event, where announcements about devices and content signal the future of VR (and AR) --with @cdixon * Google quantum supremacy claim, as shared in a paper with/via NASA: what does it mean for cryptography and other applications, where are we in quantum computing? -- with @vijaypande …hosted by @smc90.
September 28, 2019
The biggest shift in gaming happened with the combination of cloud, social, and mobile. As with all great tech shifts, though, it's really the underlying business models that really create new startup opportunities. With blockchain technology and cryptoeconomic business models, what becomes possible in gaming?
September 23, 2019
News and trends covered this week include: * FBI's latest note on social engineering of two-factor authentication * Simjacker spyware via SMS * Google Project Zero vs. Apple, and Apple's year in security * what can we do to secure ourselves? …with @martin_casado joeldelgarza and host @smc90.
September 17, 2019
What is the nature of physical pain? Why do we even experience it? Is there one type, or many? Do people experience pain differently? What is happening in our brains and our bodies when we experience pain? What is the biological link between pain and addiction? In this episode Clifford Woolf, Professor of Neurobiology at Harvard Medical School and a renowned expert on understanding pain, shares with with a16z's Hanne Tidnam all we know about the biology of pain. Technology is enabling a new, deeper, and much more complex understanding of pain—which pathways and neurons are activated in the brain when, what patterns might represent which experiences of pain. We now understand that the notion of pain as a simple switch that can be switched on or off (you have pain/you don't have pain) and measured by categories like mild, moderate, or severe is just incorrect. Woolf describes the 4 different broad types of pain we in fact experience, what the purpose of each is, and what it means now that we can phenotype them and begin to understand them as distinct. Now that we have this deeper and much more complex understanding of pain, what does it mean for how we can treat pain in the future, and where we can intervene?
September 17, 2019
What is the nature of physical pain? Why do we even experience it? Is there one type, or many? Do people experience pain differently? What is happening in our brains and our bodies when we experience pain? What is the biological link between pain and...
September 16, 2019
with @benedictevans @vijaypande and @smc90 This is episode #8 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends. This week we cover, with the following a16z experts: * Apple's latest event announcing new products and services across mobile, TV, and gaming; where is (and isn't) innovation happening, and what's next -- with a16z's Benedict Evans; * wearables and health trackers such as Fitbit supplying services to the government of Singapore, and what it means for the hype vs. reality of the current trends of wearables (and "the quantified self"); going beyond counting steps to clinical applications and detecting comorbid conditions; strong vs. weak technologies and how to pay beyond fee-for-service to fee-for-value; and where does this all fit in a sensor-ified future? -- with a16z bio general partner Vijay Pande; ...hosted by Sonal Chokshi. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
September 16, 2019
with @benedictevans @vijaypande and @smc90 This is episode #8 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our...
September 8, 2019
There's been a lot of talk about the need for our healthcare system to shift away from volume and fee-for-service, where you pay by appointment, procedure, etc, to value-based care, where you pay for both quality and outcomes—essentially, good health. But there's also been a real dearth of seeing how that might work in action, or concrete models for how to implement it at scale. In this episode, CEO of Blue Cross Blue Shield North Carolina Patrick Conway dives deep into how exactly we can make the move towards this kind of healthcare a reality, in conversation with a16z's General Partner Jorge Conde, Venkat Mocherla and Hanne Tidnam. Conway—also a pediatrician, and formerly Deputy Administrator at the Centers for Medicare and Medicaid Services (CMS) and Director of the Center for Medicare and Medicaid Innovation (CMMI)—gets into what value-based care really means; different ideas for how payors can implement the shift away from fee-for-service and volume-based care towards outcomes; as well as the critical role social determinants (food insecurity, transportation, and more) play in our health—and how tech can be a driver of change. And finally, Conway shares thoughtful analysis from an insider’s point of view from the Hill on how to actually effect change in policy and regulation in healthcare to move the entire system in this direction.
September 6, 2019
There's been a lot of talk about the need for our healthcare system to shift away from volume and fee-for-service, where you pay by appointment, procedure, etc, to value-based care, where you pay for both quality and outcomes—essentially, good health...
September 6, 2019
with @bhorowitz @shakasenghor @diishanimira @therealritabee Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms -- and mindsets -- for everybody and anybody who has the desire, the talent, and the hustle to do great things. Read more about it here.  Episode #3, "The Hustler's Guide to the Hair Business" features Diishan Imira, CEO and co-founder of Mayvenn, a technology company re-shaping salon retail distribution; Sherita (SherriAnn) Cole, who uses Mayvenn for her hair stylist business -- both interviewed by Ben Horowitz and Shaka Senghor. "Can you fit in this box? You always have to fit in a box, and for the first time in a life, it's like I didn't have to fit in anyone's box, and I could create my own box -- maybe it's not a box, maybe it’s a star shape." music: Chris Lyons
September 6, 2019
with @bhorowitz @shakasenghor ram @earnin & vaughn ferguson Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms — and mindsets — for everybody and anybody who has the desire, the talent, and the hustle to do great things. Read more about it here. Episode #2, “The Hustler’s Guide to Getting Paid” (early, but actually, on time) features Ram Palianappan, CEO and founder of Earnin, which allows workers to access their pay instantly with no fees or interest; Vaughn Ferguson, who uses Earnin to avoid overdraft fees or payday loans -- both interviewed by Ben Horowitz and Shaka Senghor. "Just knowing that more people are really using these things that are out there, to their advantage and not their detriment." music: Chris Lyons
September 6, 2019
with @bhorowitz @shakasenghor @8ennett & sherie james Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms -- and mindsets -- for everybody and anybody who has the desire, the talent, and the hustle to do great things. Read more about it here.  Episode #1, "The Hustler's Guide to Preschool" features Chris Bennett, CEO and co-founder of Wonderschool, a network of modern early education programs that helps both parents and teachers to start and manage early childhood education centers; Sherie James, who uses Wonderschool to operate her own in-home preschool and daycare -- both interviewed by Ben Horowitz and Shaka Senghor, live at the 25th Anniversary Essence Festival Global Economic Black Forum in New Orleans. music: Chris Lyons
September 6, 2019
We're excited to introduce a new podcast series hosted by a16z co-founder Ben Horowitz and Shaka Senghor, a leading voice in criminal justice reform and bestselling author. The series is called “Hustlin’ Tech” and so far, there are three episodes to follow, which you can find in this feed: #1 The Hustler’s Guide to Preschool #2 The Hustler’s Guide to Getting Paid #3 The Hustler’s Guide to the Hair Business You can read more about the what and the why of this new series -- and sign up to be notified about future episodes -- at: a16z.com/hustlin
September 6, 2019
with @bhorowitz @shakasenghor @diishanimira @therealritabee Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms -- and mindsets -- for everybody and anybody who has the desire, the talent, and the hustle t...
September 6, 2019
with @bhorowitz @shakasenghor ram @earnin & vaughn ferguson Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms — and mindsets — for everybody and anybody who has the desire, the talent, and the hustle to ...
September 6, 2019
with @bhorowitz @shakasenghor @8ennett & sherie james Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology platforms -- and mindsets -- for everybody and anybody who has the desire, the talent, and the hustle to do g...
September 6, 2019
We're excited to introduce a new podcast series hosted by a16z co-founder Ben Horowitz and Shaka Senghor, a leading voice in criminal justice reform and bestselling author. The series is called “Hustlin’ Tech” and so far, there are three episodes to ...
September 2, 2019
"You cannot be IN it... and not be OF it." Dapper Dan a.k.a. Daniel Day shares his remarkable history and story of defining an era of fashion and cultural influence in this special episode of the a16z Podcast -- based on his conversation (also available as video here) with Ben Horowitz around his memoir, Made in Harlem. Dapper Dan pioneered high-end streetwear in the early 1980s, remixing luxury brand logos into his own designs for gangsters, athletes, and musicians, dressing cultural icons from Salt-N-Pepa and Eric B. & Rakim to Beyoncé and Jay-Z along the way. Going on to define an era, his work has been featured in exhibitions at the Museum of Modern Art, the Met, The Smithsonian, and more. But he began as a hungry, fast learner in Harlem who became a gambler; spent a brief stint in a foreign jail where he nourished himself with reading; and then studied the market to build his fashion business, trendsetting the concepts of logomania and later, influencer marketing. Today, Dapper Dan has a unique partnership with Gucci and reopened his boutique in 2017. From "the struggle" when not given the privileges and opportunities that others have to the struggle of building and then losing and then reinventing oneself again and again, this special episode offers inspiration for all kinds of makers -- including the power of "studying the game"; the power of listening to your customers (not in the cliché way!); and the power of cultural influence... and voice. photo credits: Alain McLaughlin
September 2, 2019
"You cannot be IN it... and not be OF it." Dapper Dan a.k.a. Daniel Day shares his remarkable history and story of defining an era of fashion and cultural influence in this special episode of the a16z Podcast — based on his conversation in San Franc...
August 29, 2019
What can we learn from the history of the internet for the future of crypto? In this episode of the a16z Podcast, general partner Katie Haun interviews a16z co-founder Marc Andreessen -- and co-founder of Netscape, which helped popularize and mainstream the internet for many -- and who also penned "Why Software is Eating the World" (in the Wall Street Journal in 2011) and "Why Bitcoin Matters" (in the New York Times in 2014). This episode is based on a fireside chat between Katie and Marc at our inaugural Crypto Regulatory Summit, which brings together leading crypto experts and builders, other technologists, academics, industry executives, and government officials -- along with forward-thinking regulators -- to foster collaboration and the exchange of ideas around this important emerging industry. Why is crypto an important evolution (or revolution) of the internet? What can entrepreneurs, corporations, and policymakers learn from the beginnings of the browser, e-commerce, and other examples about how emerging technologies move forward?
August 29, 2019
What can we learn from the history of the internet for the future of crypto? In this episode of the a16z Podcast, general partner Katie Haun interviews a16z co-founder Marc Andreessen -- and co-founder of Netscape, which helped popularize and mainstr...
August 29, 2019
with @ldhawke and @stevesi The government wants to get onto the cloud! But how do they assess the levels of risk in adopting specific cloud products, and which "cloud service providers" (aka "CSPs") to work with? That's where FedRAMP -- the Federal Risk and Authorization Management Program -- comes in. And enterprise SaaS companies need to pay attention, since it will be a requirement for selling to the U.S. government, which is one of the biggest buyers of tech. Not just that, but even state governments and private/public companies may seek FedRAMP certification because they either work with the federal government or are just seeking standards. How similar or different is FedRAMP to other types of certification, authorization, and compliance (such as ISO, SOC-2, GDPR, even HIPAA); and what does it mean for a startup to go through organizationally, culturally? Is it like a check-the-box policy thing, is it like getting a driver's license... or what? One thing's for sure: It's an opportunity for enterprise SaaS startups, and the government is trying to help companies through the process. What are the steps to certification? What are some acronyms and terms to be aware of? When and how should you bring a consultant, advisor, or third-party auditor into the process? How long does it take, really? And how does it affect your sales team? Most importantly, what is the best strategy for moving forward? (Hint: start with a customer). Lisa Hawke, VP of Security and Compliance at Everlaw, an a16z company, shares her expertise and their experience in navigating all this, as well as the resources below, in this episode of the a16z Podcast hosted by board partner Steven Sinofsky. (The two were also previously on another episode sharing everything startups need to know about GDPR.) For links mentioned in this episode and other resources, see: https://a16z.com/2019/08/28/fedramp-why-what-how-for-startups/
August 28, 2019
with @ldhawke and @stevesi The government wants to get onto the cloud! But how do they assess the levels of risk in adopting specific cloud products, and which "cloud service providers" (aka "CSPs") to work with? That's where FedRAMP -- the Federal...
August 25, 2019
with @illscience and @smc90 This is episode #7 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends. This week we cover, with the following a16z experts: * Apple releasing a credit card, and what it means beyond the card features itself, what it means for consumer credit (and recession risks), and the financial ecosystem overall -- with new a16z fintech general partner Anish Acharya; * BEC frauds and scams indictment and the FBI bringing a massive federal grand jury indictment, one of the biggest of its kind, and what it means and how to prevent this type of cyber fraud -- with a16z operating partner for security Joel de la Garza; ...hosted by Sonal Chokshi. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
August 25, 2019
with @illscience and @smc90 This is episode #7 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views...
August 18, 2019
Back in 2011, a16z cofounder Marc Andreessen first made the bold claim that software would eat the world. In this episode (originally recorded as part of an event at a16z), Andreesseen and a16z general partner on the bio fund Jorge Conde (@JorgeCondeBio) take a look back at that thesis, and think about where we are now, nearly a decade later—how software has delivered on that promise… and most of all, where it is yet to come. In the wide-ranging conversation, the two partners discuss everything from the translatable learnings of software’s transformation of the music and automotive industries, to how software will now eat healthcare (including what exactly changed in the fields of bio and computer science to make Marc eat his own words!). *** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
August 15, 2019
Back in 2011, a16z cofounder Marc Andreessen first made the bold claim that software would eat the world. In this episode (originally recorded as part of an event at a16z), Andreesseen and a16z general partner on the bio fund Jorge Conde (@JorgeConde...
August 12, 2019
with @julesyoo @smc90 This is episode #6 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts: * health claims, insurance & big tech, and healthcare data liquidity -- with a16z bio partner Julie Yoo; * Capital One data breach, cloud security, and corporate hacks -- with a16z operating partner for security Joel de la Garza; ...hosted by Sonal Chokshi.
August 12, 2019
with @julesyoo @smc90 This is episode #6 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on the...
August 12, 2019
with @astrange @jeff_jordan and @smc90 This is episode #5 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts: * Federal Reserve real-time payment and settlement service FedNow, the U.S. payments rail, and fintech -- with a16z general partner Angela Strange; * Barney's bankruptcy, the "death of retail", and ecommerce -- with a16z general partner Jeff Jordan; ...hosted by Sonal Chokshi.
August 11, 2019
with @astrange @jeff_jordan and @smc90 This is episode #5 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our expe...
August 4, 2019
with @jorgecondebio @vijaypande and @smc90 This is episode #4 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on the opioid crisis, given recent data around where and who was behind the manufacturing and distribution of specific opioids: * How do opioids work, why these drugs? * Who's to blame? * What are other directions for managing pain -- and where could tech come in, even with the broader social, cultural, and structural context involved? Our a16z experts in this episode are a16z bio general partners Jorge Conde and Vijay Pande, in conversation with host Sonal Chokshi.
August 4, 2019
with @andrewchen @dcoolican and @smc90 This is episode #3 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on esports, given recent news of the inaugural Fortnite World Cup champion, and how this all fits into the broader trends in gaming, social networks, and the future of entertainment. Our a16z experts in this episode are general partner Andrew Chen and investing team partner D'Arcy Coolican, both of the consumer vertical, in conversation with host Sonal Chokshi.
August 4, 2019
with @jorgecondebio @vijaypande and @smc90 This is episode #4 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our ...
August 4, 2019
with @andrewchen @dcoolican and @smc90 This is episode #3 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our expe...
July 28, 2019
with @martin_casado @jorgeconde @jayrughani and @smc90 This is episode #2 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts: * . mobile malware and a recent report of a new kind in the wild and security in a post-perimeter world -- with a16z general partner Martin Casado; * drug pricing given recent proposals on the table, sharing a lay of the land for why drug pricing is so damn hard, what is a medicine, and where tech comes in -- with a16z bio general partner Jorge Conde and market dev partner Jay Rughani; ...hosted by Sonal Chokshi. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.  This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
July 28, 2019
with @martin_casado @jorgeconde @jayrughani and @smc90 This is episode #2 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- an...
July 24, 2019
with Kurt House (@kurtzhouse), John Thompson, Connie Chan (@conniechan) and Hanne Tidnam (@omnivorousread) The exploration for and mining of certain metals has driven huge epochs of human civilization, from copper and iron to gold and diamonds. In this conversation, Kurt House, CEO and co-founder of KoBold Metals; John Thompson, professor of earth and geosciences at Cornell and longtime advisor to the mining industry; and Connie Chan, general partner for consume, talk with Hanne Tidnam about why it is that cobalt is suddenly one of the most important metals on the planet. Because this metal makes today's best batteries for phones, electric cars, and more, we have gone from little to enormous demand -- with that demand expected to only increase. This conversation covers the way technology is transforming how we find cobalt, and the mining industry as a whole. Along the way we touch on the science behind why exactly it is that cobalt is so damn good in batteries; what we know about what makes cobalt as a metal 'tick', where it's currently mined, and where it's most likely to be found; what data and knowledge used to drive mining; and what the new data sources, technologies, and techniques are today, from geophysical/ geochemical data, to agricultural information, to old boxes collected over centuries in the basements and attics of mining cos…. all of this to satisfy the incredible spike of demand for this material, as we enter a new age of battery metals.
July 23, 2019
with Kurt House (@kurtzhouse), John Thompson, Connie Chan (@conniechan) and Hanne Tidnam (@omnivorousread) The exploration for and mining of certain metals has driven huge epochs of human civilization, from copper and iron to gold and diamonds. In t...
July 21, 2019
with @vijaypande @conniechan @jpm25 and @smc90 Introducing our new podcast, 16 Minutes, a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our vantage point; and what are our experts' quick takes on these trends? This is the first episode of the show, and this week we cover the below topics with the following experts: * Neuralink's recent news/ event/ whitepaper and the trend of brain-computer interfaces -- with a16z bio general partner Vijay Pande * TikTok video influencers and AI-driven media and commerce -- with general partner, consumer, Connie Chan * FaceApp and privacy beyond national security -- with operating partner, security, Joel de la Garza * iHeart Radio and direct listings -- with operating partner, corporate development, Jamie McGurk ...hosted by Sonal Chokshi. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.  This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
July 21, 2019
with @vijaypande @conniechan @jpm25 and @smc90 Introducing our new podcast, 16 Minutes, a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our va...
July 19, 2019
In this final of a 3-part series (which originally aired as YouTube videos) on working with venture investors, a16z Managing Partner Scott Kupor shares best practices for working with your board as it grows from just you, your co-founders and first investor all the way through the time when you are recruiting independent board members in preparation for going public. Want to learn more? Read Scott's book "Secrets of Sand Hill Road: Venture Capital and How to Get It" (https://a16z.com/book/secrets-of-sand-hill-road/). **** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
July 19, 2019
In this final of a 3-part series (which originally aired as YouTube videos) on working with venture investors, a16z Managing Partner Scott Kupor shares best practices for working with your board as it grows from just you, your co-founders and first i...
July 18, 2019
So you've decided raising venture capital is the best fundraising strategy for your startup. Now what? In this second of a 3-part series, a16z Managing Partner Scott Kupor shares actionable fundraising advice based on his experience of seeing thousands of startup pitches and working on all of a16z's investments. Want to learn more? Read Scott's book "Secrets of Sand Hill Road: Venture Capital and How to Get It" (https://a16z.com/book/secrets-of-sand-hill-road/). **** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
July 18, 2019
So you've decided raising venture capital is the best fundraising strategy for your startup. Now what? In this second of a 3-part series, a16z Managing Partner Scott Kupor shares actionable fundraising advice based on his experience of seeing thousa...
July 17, 2019
Incentives matter. So understanding the incentives of venture capitalists will help you decide if raising money from a venture investor makes sense for your business. In this first of a 3-part series, which originally aired as YouTube videos, a16z Managing Partner Scott Kupor talks with Frank Chen about how venture capital works: how the money flows, what Limited Partners (the organizations that invest in venture capitalists) are looking for, what differentiates the top investors, and what all of this means for an entrepreneur raising money. Want to learn more? Read Scott's book "Secrets of Sand Hill Road: Venture Capital and How to Get It" (https://a16z.com/book/secrets-of-sand-hill-road/). Stay tuned for parts 2 and 3. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
July 17, 2019
Incentives matter. So understanding the incentives of venture capitalists will help you decide if raising money from a venture investor makes sense for your business. In this first of a 3-part series, which originally aired as YouTube videos, a16z M...
July 7, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Steven Johnson (@stevenbjohnson) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2017 at our annual innovation Summit, and features technology writer Steven Johnson interviewing Ben and Marc about everything from their relationship to creative inspirations. You can find other episodes in this series at a16z.com/10.
July 7, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2018 at our annual innovation Summit, and features economist Tyler Cowen interviewing Ben and Marc about everything from their partnership and how it works to talent, tech trends, and software eating culture. You can find other episodes in this series at a16z.com/10.
July 7, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2016 -- on the 5-year anniversary of Marc’s Wall Street Journal op-ed on “Why software is eating the world” -- and features Sonal Chokshi and Scott Kupor interviewing Ben and Marc about what’s changed since, and how software is programming the world... in everything from simulations to distributed systems to other key computing shifts. You can find other episodes in this series at a16z.com/10.
July 7, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Michael Copeland Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2014, on the 5-year anniversary of the firm, and features Michael Copeland interviewing Ben and Marc about disruption theory, as well as key traits of entrepreneurs. You can find other episodes in this series at a16z.com/10.
July 4, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andr...
July 4, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Steven Johnson (@stevenbjohnson) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuri...
July 4, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous ep...
July 4, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Michael Copeland Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Ho...
June 29, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Stewart Butterfield (@stewart) A lot in technology -- and venture -- happens in decades. New cycles of technology come and go, including some secular shifts; a new generation of founders matures; and so much more changes. So when Andreessen Horowitz (dubbed with the numeronym "a16z") was founded a decade ago as of this month, the tech landscape looked very different between then and now: Not only had the global economy just seen a recession, but trends like mobile and cloud and even social were just taking off. Now, 10 years later, what's changed -- not just in tech, but in profiles of entrepreneurs? And what's changed in the firm itself, given that Marc and Ben -- the Andreessen and the Horowitz -- were yet again entrepreneurs in founding the firm too? As another repeat entrepreneur from then to now, guest host Stewart Butterfield, CEO of Slack, interviews the a16z co-founders in this special episode of the a16z Podcast to commemorate our 10th anniversary. * * * The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
June 28, 2019
with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Stewart Butterfield (@stewart) A lot in technology -- and venture -- happens in decades. New cycles of technology come and go, including some secular shifts; a new generation of founder...
June 26, 2019
Two recent scientific journal papers show what's possible when CRISPR moves from cutting DNA tool to a full-fledged platform -- expanding its toolkit for medicine across R&D, therapeutics, and diagnostics: "Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration" in Nature -- by Sanne Klompe, Phuc Vo, Tyler Halpin-Healy, and Samuel Sternberg (of Columbia University) "RNA-guided DNA insertion with CRISPR-associated transposases" in Science -- by Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan Schmid-burgk, Kira Makarova, Eugene Koonin, and Feng Zhang (of the Broad Institute) What do these two papers -- both about techniques for getting rid of the need to cut the genome to edit it -- make possible going forward, given the ongoing shift of biology becoming more like engineering? Where are we in the wave of the genome engineering "developer community" building on top of CRISPR with a constantly growing suite of programmable functionalities? a16z bio general partner Jorge Conde and bio deal team partner Andy Tran chat with Hanne Tidnam about these trends -- and these two papers -- in this short internal hallway-style conversation, part of our new a16z Journal Club series. This podcast is also part of our new a16z bio newsletter, which you can sign up for at a16z.com/subscribe
June 26, 2019
Two recent scientific journal papers show what's possible when CRISPR moves from cutting DNA tool to a full-fledged platform -- expanding its toolkit for medicine across R&D, therapeutics, and diagnostics: "Transposon-encoded CRISPR-Cas systems dire...
June 25, 2019
Synthetic fraud—yes, it's a thing: a new evolution of consumer fraud that’s been emerging in financial services, to the tune of $1-$2B a year. In this episode of the a16z Podcast, Naftali Harris, co-founder and CEO of Sentilink, which builds technology to detect and stop synthetic fraud, talks with a16z's Hanne Tidnam and operating partner for information security Joel de la Garza all about what this new kind of fraud is. Where did this new form of fraud come from, and why is it on the rise? Who are true victims here (hint: it's not the Joneses... or maybe it is!). And what is the fundamental security issue really at the heart of it all? The conversation covers the fascinating life cycle of this long con: how these “synthetic” identities get made, incubated, and finally busted out… and some of the wildest stories (and art of storytelling!) behind the strangest fraud rings we've seen. *** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. Where did this new form of fraud come from, and why is it on the rise? Who are true victims here (hint: it's not the Joneses... or maybe it is!). And what is the fundamental security issue really at the heart of it all? The conversation covers the fascinating life cycle of this long con: how these “synthetic” identities get made, incubated, and finally busted out… and some of the wildest stories (and art of storytelling!) behind the strangest fraud rings we've seen.
June 25, 2019
Synthetic fraud—yes, it's a thing: a new evolution of consumer fraud that’s been emerging in financial services, to the tune of $1-$2B a year. In this episode of the a16z Podcast, Naftali Harris, co-founder and CEO of Sentilink, which builds techno...
June 19, 2019
How have we gotten to where were are with machine learning? Where are we going? a16z Operating Partner Frank Chen and Carnegie Mellon professor Tom Mitchell first stroll down memory lane, visiting the major landmarks: the symbolic approach of the 1970s, the "principled probabalistic methods" of the 1980s, and today's deep learning phase. Then they go on to explore the frontiers of research. Along the way, they cover: - How planning systems from the 1970s and early 1980s were stymied by the "banana in the tailpipe" problem - How the relatively slow neurons in our visual cortex work together to deliver very speedy and accurate recognition - How fMRI scans of the brain reveal common neural patterns across people when they are exposed to common nouns like chair, car, knife, and so on - How the computer science community is working with social scientists (psychologists, economists, and philosophers) on building measures for fairness and transparency for machine learning models - How we want our self-driving cars to have reasonable answers to the Trolley Problem, but no one sitting for their DMV exam is ever asked how they would respond - How there were inflated expectations (and great social fears) for AI in the 1980s, and how the US concerns about Japan compare to our concerns about China today - Whether this is the best time ever for AI and ML research and what continues to fascinate and motivate Tom after decades in the field --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
June 19, 2019
How have we gotten to where were are with machine learning? Where are we going? a16z Operating Partner Frank Chen and Carnegie Mellon professor Tom Mitchell first stroll down memory lane, visiting the major landmarks: the symbolic approach of the 19...
June 16, 2019
with Tony Blair (@InstituteGC), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) If the current pace of tech change is the 21st-century equivalent of the 19th-century Industrial Revolution — with its tremendous economic growth and lifestyle change — it means that even though it’s fundamentally empowering and enabling, there’s also lots of fears and misconceptions as well. That’s why, argues former U.K. prime minister Tony Blair (who now has an eponymous Institute for Global Change), we need to make sure that the changemakers — i.e., technologists, entrepreneurs, and quite frankly, any company that wields power — are in a structured dialogue with politicians. After all, the politician’s task, observes Blair, is “to be able to articulate to the people those changes and fit them into a policy framework that makes sense”. The concern is that if politicians don't understand new technologies, then "they'll fear it; and if they fear it, they'll try and stop it" -- and that's how we end up with pessimism and bad policy. Yet bad regulations often come from even the very best of intentions: Take for example the case of Dodd-Frank in the U.S., or more recently, GDPR in Europe -- which, ironically (but not surprisingly) served to entrench incumbent and large company interests over those of small-and-medium-sized businesses and startups. And would we have ever had the world wide web today if we hadn't had an environment of so-called "permissionless innovation", where government didn't decide up front how to regulate the internet? Could companies instead be more inclusive of stakeholders, not just shareholders, with better ESG (environment, social, governance)? Finally, how do we ensure a spirit of optimism and focusing on leading vs. lagging indicators about the future, while still being sensitive to short-term displacements, as with farmers during the Industrial Revolution? This hallway-style style episode of the a16z Podcast features Blair in conversation with Sonal Chokshi and a16z managing partner Scott Kupor -- who has a new book, just out, on Secrets of Sand Hill Road: Venture Capital and How to Get It, and also often engages with government legislators on behalf of startups. They delve into mindsets for engaging policymakers; touch briefly on topics such as autonomous cars, crypto, and education; and consider the question of how government itself and politicians too will need to change. One thing's for sure: The discussion today is global, beyond both sides of the Atlantic, given the flow of capital, people, and ideas across borders. So how do we make sure globalization works for the many... and not just for the few.  image credit: Benedict Macon-Cooney --- The views expressed here are those of the individual personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors and may not under any circumstances be relied upon when making a decision to invest in any a16z funds. PLEASE SEE MORE HERE: https://a16z.com/disclosures/
June 15, 2019
with Tony Blair (@InstituteGC), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) If the current pace of tech change is the 21st-century equivalent of the 19th-century Industrial Revolution — with its tremendous economic growth and lifestyle change ...
June 13, 2019
with Eric Topol (@EricTopol) and Vijay Pande (@vijaypande) Artificial intelligence is coming to the doctor’s office. In this episode, Dr. Eric Topol, cardiologist and chair of innovative medicine at Scripps Research, and a16z’s general partner on the Bio Fund Vijay Pande, have a conversation around Topol’s new book, Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. What is the impact AI will have on how your doctor engages with you? On the nature of the doctor's visit as a whole? How will AI impact not just doctor-patient interactions, but diagnosis, prevention, prediction, medical education, and everything in between? Topol and Pande discuss how AI’s capabilities for deep phenotyping will shift our thinking from population health to understanding the medical health essence of you, how the industry might respond and the challenges in integrating and introducing the technology into today’s system—and ultimately, what that the doctor’s visit of the future might look like.
June 13, 2019
with Eric Topol (@EricTopol) and Vijay Pande (@vijaypande) Artificial intelligence is coming to the doctor’s office. In this episode, Dr. Eric Topol, cardiologist and chair of innovative medicine at Scripps Research, and a16z’s general partner on th...
June 10, 2019
Want actionable advice from a founder who has built multiple tech companies and has invested the time to be open, introspective, and transparent about lessons learned? In this episode (which originally aired as a YouTube video), a16z General Partner Andrew Chen (@@andrewchen) talks with Justin Kan (@justinkan). Justin is a repeat entrepreneur who co-founded Kiko Software (a Web 2.0 calendar that pre-dated Google Calendar by 4 years); Justin.tv (a lifecasting platform); Twitch.tv (a live streaming platform for esports, music, and other creatives now part of Amazon); Socialcam; and now Atrium, a software-powered law firm for startups. Justin reflects on his journey and shares 10 + 1 lessons he’s learned: - The paradox of choice: choosing a focus - Tradeoffs between B2B versus B2C companies - Market risk vs execution risk - Fundraising strategy: go big or stay lean? - Managing the stress of being a startup CEO (again!) - Seeking out mentors, coaches, and peers for help - Intentionally designing a culture to avoid the pitfalls of “culture eating strategy” - Things he’s still doing in his latest startup—and things he’s doing very differently - Managing higher expectations - What he’s reading and listening to - Bonus: advice he’d give his 20-year old self ***** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.
June 10, 2019
Want actionable advice from a founder who has built multiple tech companies and has invested the time to be open, introspective, and transparent about lessons learned? In this episode (which originally aired as a YouTube video), a16z General Partner...
June 7, 2019
with Vijay Pande (@vijaypande) and Bharath Ramsundar Deep learning has arrived in the life sciences: every week, it seems, a new published study comes out... with code on top. In this episode, a16z General Partner Vijay Pande and Bharath Ramsundar talk about how AI/ML is unlocking the field in a new way, in a conversation around their book, Deep Learning for the Life Sciences: Applying Deep Learning to Genomics, Microscopy, Drug Discovery, and More (also co-authored with Peter Eastman and Patrick Walters. So -- why now? ML is old, bio is certainly old. What is it about deep learning's evolution that is allowing it to finally making a major impact in the life sciences? What is the practical toolkit you need, the right kinds of problems to attack, and the right questions to ask? How is the hacker ethos coming to the world of biology? And what might “open source biology” look like in the future?
June 6, 2019
with Vijay Pande (@vijaypande) and Bharath Ramsundar Deep learning has arrived in the life sciences: every week, it seems, a new published study comes out... with code on top. In this episode, a16z General Partner Vijay Pande and Bharath Ramsundar t...
June 3, 2019
with Van Jones (@VanJones68), Shaka Senghor (@ShakaSeghnor), and Chris Lyons (@clyons) True redemption can be hard to come by in our justice system today. And yet, we need it more than ever before. In this episode (based on an event hosted by Andreessen Horowitz's Cultural Leadership Fund), CNN news commentator and author Van Jones and Shaka Senghor, author of the New York Times bestseller Writing my Wrongs and director's fellow of the MIT Media Lab, discuss the U.S. prison system; the human potential for redemption; and how we begin to go about normalizing restorative justice in our society. The conversation, introduced by a16z partner Chris Lyons, followed screening of an episode of Van Jones' new series, The Redemption Project. The eight-part series looks at the families of victims of a life-altering crime as they come together to meet their offender; this episode featured the meeting between a police officer along with the man who shot him as a young boy of 17 years, decades earlier. The episode also includes two spoken word performances before and after the conversation, from two formerly incarcerated artists: first, Kevin Gentry, with "My Heart"; and second, Missy Hart, with "Bloom: A Trilogy." Both are contributors to The Beat Within, a publication and organization that serves youth across California country juvenile halls and encourages literacy, self-expression, and community.
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