The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Diet Soda Brain Aging, Hidden Heart Attack Risk, New Cholesterol Pill, Lettuce Recall, and more...  : 1507
This episode breaks down the latest health research and news — from artificial sweeteners and muscle fat harming cardiovascular health, to a new cholesterol pill, a lettuce-borne outbreak, the gut-brain connection to anxiety, and a banana-blueberry smoothie myth — with practical takeaways and predictions for where the science is heading.
Jul 24
12 min
The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506
Dave Asprey and microbiologist Kiran Krishnan discuss how spore-based probiotics (like Just Thrive) combat gut endotoxins to improve testosterone, body composition, bone density, and overall longevity.
Jul 23
1 hr 7 min
The Truth About Visceral Fat vs Subcutaneous Fat | Dr. Sean O’Mara  : 1505
Dave sits down with Dr. Sean O'Mara to break down the critical difference between visceral and subcutaneous fat, revealing why a six-pack can hide disease, how MRI scans expose what the mirror can't, and the fasting and microbiome strategies that build the fat you actually want.
Jul 21
1 hr
If I Only Had $200 to Reverse My Age... : 1504
Dave Asprey breaks down a complete $200 biohacking stack—red light bulbs, blackout curtains, light-blocking glasses, creatine, MCT oil, spermidine, and magnesium—that improves sleep, brain energy, and cellular repair without needing expensive protocols.
Jul 19
20 min
The Science And Health Of Community Eating (How Many Times A Week?) : 1503
Shawn Stevenson reveals the minimum number of family meals per week that measurably lowers a child's risk of obesity, and why eating together may be the most overlooked longevity habit in modern life.
Jul 17
1 hr 17 min
Here's Why Your Supplements Don't Seem To Work | Nayan Patel  : 1502
Dr. Nayan Patel reveals why oral, liposomal, and even IV glutathione never actually reach your cells, and the transdermal delivery breakthrough that finally does.
Jul 16
58 min
Peter McCullough: Spike Protein Detected 3.6 Years After the Shot (Detox Protocol)  : 1501
Dr. Peter McCullough traces the spike protein's origins to 2015 gain-of-function research, explains why it can persist in the body for years after vaccination, and breaks down the science behind clearing it, the suppression of early COVID treatments, and what he'd change if he ran HHS.
Jul 14
1 hr 27 min
This Ancient Hack Reverses Aging In 72 Hours : 1500
A Japanese village's daily breakfast of natto — rich in spermidine — triggers the Nobel Prize-winning cellular repair process of autophagy, reversing biological aging within 72 hours when combined with proper dosing, exercise, sleep, and diet.
Jul 12
14 min
Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine  : 1499
Jordan Harbinger joins Dave Asprey to share how he talked his way out of two kidnappings and breaks down the psychology-driven systems — calendar blocking, pain-point habit hacks, and relationship-building — he uses to stay productive and charming under pressure.
Jul 10
1 hr 8 min
The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter  : 1498
Dave Asprey sits down with Dr. David Perlmutter to explore how brain inflammation and microglial dysfunction drive Alzheimer's, Parkinson's, and other neurodegenerative conditions — debunking the amyloid hypothesis along the way and examining emerging treatments like GLP-1 drugs, 40 hertz light therapy, and lifestyle interventions.
Jul 9
53 min
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