The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Brain-Cleaning Beds, Forever Chemicals, Peptide Freedom, Coffee for Your Heart, and More : 1568
Dave Asprey breaks down new research on brain waste clearance, taurine and inflammation, removing forever chemicals through plasma donation, expanded access to experimental peptides, and coffee’s surprising effects on heart rhythm.
Nov 6
10 min
How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder  : 1569
Dave Asprey sits down with Roman Tsunder to explore the psychology of high achievement, the power of obsession and focus, overcoming fear and failure, and how to pursue extraordinary success without sacrificing your health, happiness, or well-being.
Nov 5
58 min
The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley  : 1567
Dave Asprey sits down with a compounding pharmacy expert to explore how pharmaceutical companies profit from nature-inspired medicines, why personalized treatments are gaining traction, and how creatine, methylation, and advanced lab testing could reshape the future of healthcare.
Nov 3
1 hr 7 min
I Tried EVERY Controversial Focus Drug : 1566
Dave Asprey shares what he learned testing every controversial and banned focus drug over 25 years, ranking modafinil and racetams as the best performers while crowning pharmaceutical nicotine as the king of focus drugs for its proven cognitive benefits, low cost, and legal accessibility when used safely.
Nov 1
38 min
Placebo Pills, Cannabis, Wall Squats for Blood Pressure, Birdwatching, and the Porn brain : 1564
Dave Asprey explores how placebo pills can relieve symptoms even when patients know they're fake, how wall squats can lower blood pressure, why birdwatching may benefit brain health, and what research reveals about THC, rapamycin, pornography, and the brain's reward system.
Oct 30
10 min
The No-Brainer Solution To Stop Overeating  : 1565
Dave Asprey sits down with Calocurb CEO Sarah Kennedy to explore how bitter hops compounds stimulate natural GLP-1 and other satiety hormones to reduce appetite, support weight loss, target visceral fat, and preserve muscle without injectable weight-loss drugs.
Oct 29
51 min
The Easiest Treatment That Made Me 15 Years Younger  : 1563
Dave Asprey and Dr. Tim Cook explore experimental gene therapies, stem cell re-education, and emerging longevity technologies that could reverse biological aging, rejuvenate the immune system, build muscle, and extend human lifespan.
Oct 27
43 min
How To Reverse Your Age For $5 Day (Budget Biohacking) : 1562
Dave Asprey reveals how to build a science-backed longevity routine for less than $5 a day using affordable supplements, better sleep, sunlight, walking, and simple habits that support healthy aging without expensive biohacks.
Oct 25
24 min
Avoid THESE "Healthy" Superfoods  : 1561
Dave Asprey and integrative practitioner Terry Cochran discuss how four metabolic disruptors — amyloids, oxalates, sulfur malabsorption, and histamine — are hijacked by industrial food, glyphosate, and the spike protein, and share practical strategies for clearing these burdens through diet, supplements, and enzymes.
Oct 23
1 hr 15 min
How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559
Dave Asprey and Steven Kotler explore the neuroscience of flow states, psychedelics, brain chemistry, trauma, consciousness, and how to train your brain for peak performance without relying on drugs.
Oct 22
56 min
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