The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Dave Solo Pod: The Original Smart Drug Masterclass  : 1518
Dave Asprey breaks down piracetam and the racetam family, the original nootropics that launched the smart drug movement, covering how they work, who benefits, proper dosing, and the safety and regulatory landscape around them.
Aug 13
41 min
Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life   : 1517
Dr. Steven Greer, a retired emergency physician and 35-year UFO researcher, joins Dave Asprey to make the case that extraterrestrial intelligence is already interacting with Earth, that suppressed free-energy technology could end global poverty, and that humanity's future depends on a truthful—not weaponized—disclosure before it's too late.
Aug 11
1 hr 11 min
300mg Improves Appearance of Wrinkles In 7 Days (Study) : 1516
Skin ages faster when oxidative stress overwhelms your defenses, so this episode explains why glutathione — the body's master antioxidant — protects collagen better than collagen itself, and how a new delivery system (RO-GSH) finally makes topical glutathione work, visibly improving wrinkles and skin tone in just one week.
Aug 9
13 min
Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more...  : 1515
This week's biohacking roundup covers a drug-repurposing screen for longevity, protein restriction's anti-aging effects via FGF21, a new cadaver-derived skin injectable, arts engagement slowing biological aging, and a review of 41 studies testing biohacking interventions (including semaglutide) against epigenetic clocks.
Aug 7
10 min
Here's How You Can Have a 3-hour Orgasm (real!)  : 1514
Author Regena "Mama Gina" joins Dave Asprey to reveal how embracing pleasure, embodiment and reverent surrender heals trauma, restores intuition and unlocks the divine feminine in women and men alike.
Aug 6
1 hr
I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic  : 1513
Dr. Vivek Lal, the physician scientist who discovered the gut-lung axis, joins Host Dave Asprey to reveal how your gut bacteria control lung inflammation through the MMP-9 pathway, and why fixing your lung microbiome may be the next frontier in longevity and respiratory health.
Aug 4
1 hr 12 min
I Wish I Knew This Anti-Aging Hack Sooner : 1512
This episode explains how aging is driven by declining antioxidant defenses and mitochondrial damage, and makes the case for glutathione—delivered topically via Glutaryl—as a practical way to support cellular repair.
Aug 2
13 min
Chicken Diarrhea, TV Kills You Quicker, CO2 for Health, Deadly Hot Neighborhoods, and more...  : 1511
This episode covers five health research stories: sildenafil's anti-cancer potential, TV watching's effect on brain aging in men, ambient heat's impact on biological aging, superbug risks from industrial chicken farming, and a CO2-based technique to trigger the brain's glymphatic waste-clearance system.
Jul 31
8 min
The $18 Million Pills Nobody Can Explain | Igniton : 1510
Ashley Grace, executive at Igniton, joins Host Dave Asprey to unpack the science behind subatomic particles called ignitons and how a private $18 million lab charges supplements to boost memory, sleep, and longevity.
Jul 30
55 min
I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem : 1509
A urologist joins the podcast to discuss penis enlargement procedures (fillers, traction, surgery), men's health and confidence, and the growing use of peptides (PT-141, BPC-157, SS-31) and TRT amid ongoing regulatory battles over compounding pharmacy access.
Jul 28
58 min
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