Today, Brent has a discussion with Dr. Paul Robbins, a pioneer in the field of cellular senescence, to explore how senescent cells contribute to aging and age-related disease, and why scientists believe eliminating them could help extend healthy years of life. Robbins explains the current state of senolytic therapies, the promise of partial cellular rejuvenation, and why breakthroughs like Yamanaka factors have generated so much excitement in longevity research. The conversation also examines GLP-1 drugs, metformin, supplements, and the risks of getting ahead of the science, while offering a realistic perspective on whether humans will ever live to 150. He's a wonderful guest, hope you enjoy.

This week, Dr. Brian Feeley, Chief of Sports Medicine and Shoulder Surgery at UCSF and team physician for the San Francisco Giants, joins the shoe to share what decades of treating athletes and everyday patients have taught him about movement, strength training, and injury prevention. The discussion covers everything from running, skiing, cycling, and youth sports to shoulder impingement, ACL tears, and the realities of exercising in middle age. Feeley explains why many common beliefs about joint health and injury risk don't hold up to the evidence, how to think about strength training without getting sidelined, and why variety may be one of the most overlooked components of a sustainable fitness routine. They also discuss the hype surrounding peptides, the science of recovery, and the emerging research on muscle regeneration and healthy aging. It's a jam-packed episode and Dr. Feeley is a wonderful guest, hope you enjoy.

In this episode of Death Clock, Brent sits down with Dr. Edward Calabrese, the scientist who helped pioneer the modern understanding of hormesis: the idea that low doses of stress can trigger powerful adaptive responses that make the body more resilient. The conversation explores how hormesis shows up in exercise, fasting, heat exposure, cold exposure, and even surprising areas like radiation and toxicology. Along the way, Calabrese shares the lifestyle habits he has followed for decades, from daily exercise and intermittent fasting to an unconventional one-meal-a-day routine, and explains why he believes strategic stress may be one of the most underappreciated tools for improving health and longevity. He's a fascinating guest, hope you enjoy.

This week, Brent speaks with Dr. Stephanie Cook, a researcher specializing in stress and cardiovascular health, who breaks down the science of chronic stress, cortisol, and the body's stress-response system. She explains how stress can influence everything from sleep and inflammation to heart disease risk, why our perception of stress matters as much as the stressor itself, and how factors like relationships, social support, income, and environment shape our ability to recover. The conversation also explores the role of social comparison, the health consequences of discrimination and inequality, and the emerging impact of algorithms and digital life on modern stress. She's a wonderful guest, hope you enjoy. We will be dark next week for the holiday. See you on 7/10 for a brand new episode.

In this episode, Brent speaks with physician-scientist Dr. Loren Walensky to explore the rapidly growing world of peptides, GLP-1 drugs, and experimental health interventions. As compounds like semaglutide, BPC-157, and other peptides gain popularity in wellness and longevity circles, Walensky explains the critical difference between therapies that have been rigorously tested and those that are being used long before the science is settled. The conversation covers obesity, willpower, off-label prescribing, the role of the FDA, and why promising treatments still need evidence before they can be considered safe and effective. He's as credentialed as you can get on this topic, hope you enjoy.

In this episode, preventive cardiologist Dr. Ann Marie Navar, a member of the committee that helped shape the American Heart Association's new recommendations for earlier cholesterol management, explains why many experts believe cardiovascular prevention should begin decades before most people ever experience symptoms. Dr. Navar explains why lowering LDL cholesterol earlier in life can have lasting benefits decades later, how ApoB and lipoprotein(a) are reshaping the way experts think about heart disease risk, and why some of the most popular fears surrounding statins aren't supported by the evidence. The conversation also explores the growing divide between evidence-based medicine and the wellness industry and the challenges of separating compelling biological theories from treatments that have actually been proven to improve health outcomes. She's a wealth of knowledge and a wonderful guest. Hope you enjoy.

This week on Death Clock, Dr. Katherine Ramos of Duke University breaks down the growing body of research linking social connection to longevity, resilience, and quality of life. Dr. Ramos explains why meaningful connection is deeply individual, and why having people who truly understand, support, and ground you can shape both mental and physical health outcomes over time. The conversation moves from marriage and friendship to parenting, caregiving, support groups, and the psychology of belonging. This episode is ultimately about learning how to build relationships that don't just help us live longer and better. Hope you enjoy.

This week, Brent sits down with Dr. Nancy Keller, one of the world's leading experts on fungi and mycotoxins, to explore how mold actually affects human health. Dr. Keller explains how certain fungi produce toxic compounds that can contaminate crops like peanuts, corn, and apples, why improper food storage is often the real culprit, and how modern food systems work to reduce those risks. The conversation examines the difference between visible mold and invisible mycotoxins, the surprising ways fungi use these chemicals to compete with other microbes, and why some of the most dangerous exposures are concentrated in parts of the developing world. They also dive into the controversial topic of mold in homes, separating well-established risks from claims that remain scientifically uncertain. Dr. Keller is a wonderful guest with decades of experience in the field. Hope you enjoy.

In this episode, Brent speaks with Dr. David Hafler, a pioneering neurologist and immunologist whose research helped establish multiple sclerosis as an autoimmune disease and reshape how it's treated today. Drawing on decades of work at both Harvard and Yale, Dr. Hafler explains the emerging evidence connecting Epstein-Barr virus to MS, why certain genetic profiles may leave people unable to fully clear the virus, and how early intervention has transformed outcomes for many patients. The conversation also covers how inflammation works, why autoimmune diseases may be an evolutionary tradeoff, and what researchers are beginning to uncover about the links between the gut, brain, and neurodegenerative disease. They also explore the surprising role of salt in inflammatory responses, the promise of new Parkinson's prevention trials, and why Hafler believes we may be entering a golden age of medical science. He's a wonderful guest, hope you enjoy.

In this episode, Brent speaks with Dr. Ryan Vandrey of Johns Hopkins to take a closer look at cannabis. With more than two decades of research in behavioral pharmacology, Dr. Vandrey walks through how THC and CBD actually interact with the brain and body, why addiction is often misunderstood, and how factors like dose, delivery method, and individual biology can completely change the experience. The conversation examines where cannabis has proven medical value, where the data is still thin, and how legalization has outpaced the kind of rigorous science typically required for new therapies. They also explore the realities of withdrawal, the overlap with mental health and sleep, and what emerging research could reveal about more targeted, effective uses in the future. It's a nuanced, data-driven look at a topic that's often oversimplified, hope you enjoy.