This podcasts reviews the pathological changes that can occur in Barrett's oesophagus. Understanding the difference between metaplasia and dysplasia and recognising the grades of dysplasia is key to understanding current management strategies. This will be covered in the next "Rest & Digest" Podcast brought to you by MIGe diagnostics (www.mige-diagnostics.co.uk).

In this podcast, we discuss clinical presentation of heartburn and non-cardiac central retrosternal chest discomfort or pain that fails to respond to a trial of anti-secretory therapy in primary care. This small group of patients should be referred to a specialist gastrointestinal centre with facilities to perform manometry and 24 hour pH testing.

What is heartburn? How does it present? How does the doctor classify heartburn and how does this affect treatment?

What is diarrhoea, pseudo-diarrhoea and constipation? Interpretation of these often used terms needs clear definition to assure appropriate investigation, explanation and management. This podcast provides some clarification for both docs and patients.