Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells.

Dr. Amit Sharma leads the senescence immunology group at the Lifespan Research Institute, where his lab studies how natural killer cells and gamma delta T cells interact with senescent cells — and how that relationship breaks down with age. In this conversation, we explore the biology of immune surveillance of senescence, why it fails as we get older, and what his lab is doing to restore and enhance it. We also discuss the iron-ferroptosis connection, next-generation senolytics, and what the next decade might bring for senotherapy.

🌐Links in this video

Lifespan Research Institute: https://lifespanresearchinstitute.io

Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/

Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu

Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan