Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly.
Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, including why they get the same diseases as the rest of us, just decades later, and what that means for the goal of longevity medicine. We then move into the practical territory: what criteria distinguish a drug that treats one disease from one that may target aging itself, which four currently approved drugs score highest on that framework, and how leading longevity physicians are beginning to use them in practice. We also discuss GLP-1 agonists in depth; their mechanisms, the emerging evidence for benefits well beyond weight loss, and the important caveats around muscle loss. Essential viewing for anyone following the science of healthy aging.
🌐Links in this video
Dr Barzilai at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai Healthy Longevity Medicine Society https://hlms.co/ American Federation for Aging Research https://www.afar.org/ Academy for Health & Lifespan Research https://www.ahlresearch.org/
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