GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs.
We go far beyondweight loss. Dr. Kolonin explains how GLP-1 drugs trigger IL-6 signaling in fattissue, activating a thermogenic program that converts metabolically inactivewhite fat into energy-burning brown fat and how in some patients this isaccompanied by upregulation of telomerase, a protein with profound implicationsfor mitochondrial health and aging. We also tackle the muscle loss questiondirectly, examining what the latest research reveals about why lean mass losson GLP-1s exceeds simple caloric restriction, and what can realistically bedone about it.
🌐Linksin this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9
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