Getting physically injured is no fun—it can often take long periods of time to recover. What if we could accelerate the wound healing process? Here, Kellen dissects an original article, titled “The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin”, that reveals mechanisms underlying skin injury and identifies novel therapeutic approaches to speed up healing. The report was written by Jeremy Di Domizio et al. and was published in Nature Immunology in July of 2020. Paper: https://www.nature.com/articles/s41590-020-0721-6 Commentary: https://www.nature.com/articles/s41590-020-0755-9?proof=t Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Cutting-edge approaches to combat tumor development involve transplantation of anti-tumor T cells and natural killer cells. Natural killer (NK) cells belong to a greater family of innate lymphoid cells which includes the more recently described group 1, 2, and 3 innate lymphoid cells (ILCs). Unlike NK and T cells, the role of non-NK ILCs in tumor immunity remains unclear. In this episode, Kellen highlights a 2020 report in Nature describing the role of ILC2s in pancreatic cancer. The article was written by John Alec Moral and colleagues and is titled “ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity”. Paper: https://www.nature.com/articles/s41586-020-2015-4 Review: https://pubmed.ncbi.nlm.nih.gov/30209347/ Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Fragile X syndrome is a genetic disorder and the leading cause of intellectual disability and autism. There is no treatment. In this episode, Kellen discusses recent gene therapy advances for treating Fragile X syndrome. The article highlighted in this episode was written by X. Shawn Liu and colleagues from Rudolf Jaenisch’s lab at the Whitehead Institute and is titled “Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene”. Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375087/ Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Medical systems around the world need our help with COVID19. After sharing an important PSA, Kellen dives into the topic of unconventional T cells. These novel immune subsets have unique functions with great therapeutic potential. In this episode, a seminal paper by Michael Crowther and colleagues is discussed. It’s titled, “Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1”. Paper: https://www.ncbi.nlm.nih.gov/pubmed/31959982 Review: https://www.ncbi.nlm.nih.gov/pubmed/30397170 Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Antibiotic resistance is an enormous public health problem. The prevalence of superbugs is increasing over time, whereas the number of drugs available to treat these microbes is not. Bacterial communities called biofilms harbor strains of bacteria that persist in the face of antibiotic therapy. Thus, in order to tackle the problem of antibiotic resistance, we must better understand biofilms. In this episode, Kellen covers a recent report on this topic by Fransisco Diaz-Pascual and colleagues titled, “Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function”. Paper: https://www.ncbi.nlm.nih.gov/pubmed/31659297 Review: https://www.ncbi.nlm.nih.gov/pubmed/31295420 Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Engineering bacteria to kill cancer cells… Sounds like science fiction, right? Well, it’s actually all science, no fiction! Sreyan Chowdhury and colleagues from Tal Danino’s lab at Columbia University describe this novel therapeutic approach in their recent Nature Medicine publication, “Programmable bacteria induce durable tumor regression and systemic antitumor immunity”. Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688650/ Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558487/ Video: https://www.youtube.com/watch?v=fnpIIZrjMtM&t=18s Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

In this episode, Kellen covers a topic near and dear to his heart – group two innate lymphoid cells, or ILC2s. Specifically, Kellen discusses the original article titled “Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte–dendritic cell antigen presentation”, which was published in the journal Science Immunology in November 2019 by Dhiren Patel and colleagues. Paper: https://immunology.sciencemag.org/content/4/41/eaax7006/tab-pdf Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614509/ (shameless self-promo) Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

When most people think of viruses, they usually think of the negative aspect of viruses –- agents of infectious disease. We, however, are not most people! Not only are viruses useful biotechnological tools, but they are also capable of promoting health outcomes in disease models. In this episode, Kellen covers a report released in December 2019 in Nature Immunology by Lei Liu, Tao Gong, and colleagues titled “Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling”. Paper: https://www.nature.com/articles/s41590-019-0513-z Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140792/ Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Plants are a great source of fiber and micronutrients, which makes them an important component of a heathy diet. However, it was recently shown that there is another aspect of plants that allows them to contribute to well-being –- exosomes. In this episode, Kellen reviews a paper published in 2018 in Cell Host & Microbe by Yun Teng and colleagues titled “Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota”. Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746408/ Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].

Brief introduction of what this podcast will entail and the reason behind its creation. Please take a few minutes to write us a review wherever you listen to podcasts -- it will help us better spread science! Want to learn more? Check out the Inflammatory Content website www.inflammatorycontent.com Finally, please send any questions or comments to Kellen on Twitter @KellenCavagnero or email [email protected].