Mitochondrial peptides may be promising, but they cannot replace the aerobic base that makes their effects measurable. Dr. Dwayne Jackson explains AMPK and mitochondrial signaling, what MOTS-c and SS-31 can and cannot tell us, and why fitness data, training, and recovery come before any experimental compound.

Dr. Emily Werner — team dietitian for the Philadelphia 76ers (NBA) and Philadelphia Flyers (NHL), and Nutrition Affairs Sport Lead at Timeline — joins Dr. Mike to unpack postbiotics, urolithin A, and why mitochondrial health matters for pro athletes and everyday people alike. They dig into the real research behind Timeline's Mitopure, how Emily navigates athlete psychology and supplement fads, and why chasing $200K gadgets rarely beats getting the fundamentals right.

Nutrition and exercise coach Zach Moore joins Dr. Mike to strip fitness back to fundamentals — why most lifters overthink programming, how to build strength with minimal volume, and why gut health and micronutrient status quietly determine whether your diet actually works. If you've been chasing complicated protocols instead of the basics, this conversation is your reset.

Getting better doesn't make hard things feel easier—it makes you capable of doing more. Cliff Wilson explains the mental skills behind elite physiques, why context beats internet absolutes, and how great coaches turn research, experience, and failure into better decisions.

Peptides are everywhere right now, but most of what's sold online as BPC-157 or TB-500 is illegal — and the FDA is about to decide what happens next. Attorney Rick Collins, a leading defense lawyer in this space, breaks down the science, the gray market, and why the military's new testosterone screening policy matters too.

Sam Brown spends his days training Air Force pilots and aircrew who run on nicotine, caffeine, and alcohol — and almost never turn off their nervous system. He reveals why the toughest operators need recovery just as much as intensity, how he sneaks down-regulation into workouts disguised as hard training, and what years of coaching in Altus, Oklahoma taught him about real performance under extreme cognitive load.

Dr. Krista Scott-Dixon reveals the counseling techniques that most nutrition coaches have never learned — and why mastering them matters more than any protocol. She explains why over-optimized clients are often the most fragile, how AI is eroding the critical thinking skills coaches rely on, and what her 700-page textbook Applied Nutrition Coaching and Counseling teaches coaches to do when clients say the unexpected.

Paul Oneid tore both quads and rebuilt himself from powerlifter to trail runner, with coach Cody Miller guiding the transition. They break down the emergent training approach, VO2 max and cardiac adaptations, and the mental side of suffering across strength sports and endurance.

Can you really build more muscle just by rethinking how you dose leucine and essential amino acids? Dr. Daniel A. Traylor, Ph.D. — co-founder and principal scientist of LEUVATE™ — reveals the science behind protein quality, muscle protein synthesis, and why older adults may need twice the protein dose to get the same results as younger people.

Dr. Mike T. Nelson explains why sleep—despite being a massive physiological lever—ranks last among the eight interventions in the Flex Diet Certification. The key concept: coaching leverage (physiology × psychology). Sleep scores high on physiology but rock-bottom on a client's ability to change, while protein scores high on both, making it the #1 starting point.