Eating For You
Eating For You
Sallyanne Pisk
Episode 157: Why Weight Regain Happens After Weight Loss Medications
32 minutes Posted Jan 25, 2026 at 7:00 pm.
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Show notes

Weight loss medications like Ozempic, Wegovy and Mounjaro are everywhere right now—and if you’re curious about them (or taking one), there’s nothing wrong with you.


In Episode 157, as a non-diet, mindfulness-based dietitian, I unpack what the research shows about weight regain after stopping weight loss medications and why regain is often biological, not a personal failure.


You’ll learn how GLP-1 medications work, the side effects people don’t always understand, and why focusing on body composition (muscle vs fat) matters more than a number on the scale.


You’ll also hear a research-based comparison of regain after medication versus regain after lifestyle and behavioural programs—including why long-term support, resistance-based movement and personalised nourishment can make a difference.

In this episode:

  • How GLP-1 medications work (appetite suppression + regulation)

  • Why side effects can unintentionally reduce protein intake and movement

  • What a 2025 systematic review found about weight regain after stopping medication

  • Why muscle preservation changes the whole story

  • Medication regain vs lifestyle-program regain: timelines and what’s different

  • A more realistic question: is it even helpful to expect a stable weight across life stages?

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