Past, present and future of therapeutic hypothermia.Targeted temperature management (TTM) or Therapeutic hypothermia is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty.TTM-2 trial was recently published in NEJM (June 2021).The TTM-2 trial tried to answer the question if Therapeutic hypothermia is any better than normal temperature in patients who are in coma after being resuscitated from cardiac arrest. I have briefly discussed the trial, also touching briefly the recent and upcoming trials of hypothermia protocol.Do watch/ listen.