In stent restenosis is common after POBA. in the era of DES also, it is responsible for 10% of all PCI. In this podcast i have discussed about definition of ISR (in stent restenosis), classification of ISR (in stent restenosis), risk factors of ISR (in stent restenosis), investigations of ISR (in stent restenosis), management of ISR (in stent restenosis). What is the role of DAPT, drug coated balloon and drug eluting stent in management of ISR. What are the recommendations of EAPCI for ISR management.When to use DEB? When to use DES?