The pineal endocrine hormone melatonin proximally decreasesIL-1β-induced MMP production by inhibiting Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes;  since autoinflammatory  Osteoarthritis (OA) is a degenerative joint (cartilage degradation) disease linked to human aging and Interleukin-1β  contributes to OA pathogenesis by enhancing oxidative stress and inflammation the role(s) of sirtuin and NAD+ metabolism is associated with aging morbidity while also being described in Double-Stranded Break (DBS) DNA Damage Repair (DDR), we have isolated and identified with distinction, pathobiochemical components of the human aging event ontology.

Oncotarget. 2017 Aug 22; 8(34): 55967–55983.

PLOS One .November 25, 2014https://doi.org/10.1371/journal.pone.0113939

Int J Mol Sci. 2019 Mar; 20(5): 1223.

eLife 2020;9:e55828 DOI: 10.7554/eLife.55828