This episode lays the foundation for a common precursor-the essential amino acid L-tryptophan, of both melatonin and NAD+ and the PARP mediated DNA repair pathways linked to tumorigenesis &nbsp;on one hand and in DNA Damage repair-linked cessation of apoptosis on the other, in the aging &nbsp;human Central Nervous System.
Cells. 2019 Sep; 8(9): 1047.
Int J Alzheimers Dis. 2011: 741974.

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L-TRP is precursor to MEL and NAD ;Mel regulates Sirtuins which Perform DSB repair; NAD metabolism after SIRT activity yields PAR for SSB repair. DJGPhD 21 Oct 2020.

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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.