Dr. Guerra offers a deep investigation into the roles of sirtuins in homeostasis , aging and disease as linked to NAD+ metabolism via ecto enzymatic CD38 and intracellular forms of this NAD+ metabolizing enzyme that is associated with T lymphocyte bioenergetics, activation and regulation as embedded within the inflammatory response, disease and aging. Published in Authentic Biochemistry Podcast series on Aging and the immune system. 14 October 2020

Papers mentioned in today's lecture :

Hogan, et al. Front. Immunol., 31 May 2019 |

Cells 2020, 9(1), 228

Camacho-Pereira et al., 2016, Cell Metabolism 23, 1127–1139

Sci. Signal. 10, eaal3024 (2017) 17 October 2017

November 2011 Pharmacological reviews 64(1):166-87