Robotics never got the internet's gift of free training data, so someone has to manufacture it. Josh Gao, founder and CEO of Mecka AI, runs one of the largest robot data factories, and he explains what that actually involves: custom baseball caps and tactile gloves because nothing off the shelf captures force, 100-gigabit upload lines to move hundreds of petabytes, and custom quality gates. Josh lays out the training recipe the industry is converging on (roughly a million hours of egocentric human data, tens of thousands of hours of robot data, and a few hours of in-domain teleop ) and why tactile and simulation data still have to enter the "data pot of soup." He argues the field is still orders of magnitude behind Tesla's FSD, which spent a decade on two degrees of freedom while a robot hand has dozens. His take: there won't be a single GPT-3 moment for robotics, but a steady unlock of commercial tasks, starting with constrained industrial work and ending, he hopes, with robots mining asteroids. Hosted by Sonya Huang, Sequoia Capital 0:00 – Introduction 1:46 – What Mecka is: pixels, actions and logic 2:45 – Is robot data economically feasible without the internet? 4:15 – Teaching robots about carbon life 5:27 – Cloud kitchens, stablecoins and the path to robotics 7:03 – Entering robotics with a fresh lens 8:45 – What egocentric data is and why Mecka bet on it 10:09 – The first pilot: aunties and uncles with a mobile app 10:42 – Force data and tactile gloves 11:55 – Inside the operations of a data factory 14:41 – Heat-mapping the taxonomy of human work 15:42 – Quality gates, fraud and the McDonald’s POV videos 17:44 – Earning a margin as a data intermediary 19:33 – Millions of hours vs. Tesla’s decade 20:55 – Why it isn’t binary: unlocking commercial tasks along the way 22:02 – Home data is plentiful; home robots are the hardest 23:24 – Useful robots can be deployed today 24:35 – When robotics gets an FSD-style flywheel 26:42 – Deployment diffusion and the modern systems integrator 28:21 – Favorite vertical robot categories; mining an asteroid 30:08 – The hardware slate: Waymo-fying people 30:55 – EgoVerse 32:04 – The data pot of soup: the converged training mix 33:54 – Move 37 for robotics: AlphaGo and Federer 36:02 – World models and the training mix 36:58 – Will scaling the current mix get us to the promised land? 39:05 – Will the AGI labs steamroll robotics? 40:50 – Sci-fi roots and the Kawasaki Corleo 42:44 – How many robots in a decade?

David Silver spent two years building AlphaGo on human data. When he removed human data altogether building AlphaGo Zero, the AI surpassed AlphaGo in under two days. He left DeepMind to run that same bet in pursuit of superintelligence. David and Lasse Espeholt, co-founders of Ineffable Intelligence, explain their plan to build a “superlearner”—an agent that starts knowing nothing and discovers science, mathematics, and language for itself by direct experience instead of through a pre-training run. Silver argues that human-language reasoning is a ceiling, not a foundation, that alignment via chain-of-thought monitoring is already reaching its limits, and that the science of how superintelligences coexist should be worked out in simulation before anything touches the real world. Espeholt describes the GPU cluster and the lineage from IMPALA and SEED RL that makes the experiment possible. Silver’s forecast: strong evidence within a year, superintelligence in three. Hosted by Sonya Huang, Sequoia Capital 0:00 – Introduction 1:09 – What held true from Go to today, and what the LLM era changed 3:35 – Why leave DeepMind to start a new lab 5:58 – Why "Ineffable" (and the secret second reason) 7:03 – Lasse's path: scaling RL at DeepMind and Google Brain 9:31 – Defining a super learner and first contact 12:35 – Super learners vs. LLMs that make discoveries 13:59 – Day to day: the RL stack, crucibles and human-journey milestones 16:13 – Don't breadcrumb the objective: simple rewards, emergent complexity 21:16 – What a crucible looks like 24:14 – Go: one agent is boring, two is infinite 25:41 – Will agents rediscover language? 27:22 – Removing human priors: AlphaGo to AlphaZero 32:05 – Keeping human bias out of the crucibles 33:35 – Confidence, timing and super forecasting 36:24 – Is compute the driver? 38:13 – The ceiling on simulation and Rich Sutton's objection 43:44 – Alignment and the science of superintelligence 47:45 – Monitoring agents that don't think in English 51:01 – Pacing the frontier 52:54 – The compute setup: Vera Rubin on GCP 55:18 – Training, inference, simulation and RL scaling laws 57:40 – IMPALA and SEED RL 1:00:58 – 20 people and the compute-per-person ratio 1:04:49 – A research-led culture 1:05:47 – Predictions

At 100,000-accelerator scale, something fails multiple times an hour, which is why Google's Chief Technologist for AI Infrastructure Amin Vahdat thinks FLOPS is a vanity metric. The metric that matters is what he calls goodput: the useful work a workload actually delivers through real failures. Amin walks through the calculus that split the TPU line into 8i and 8t for the first time, why the TPU's core primitives haven't changed since v1, and how Google and DeepMind co-design in the same rooms, intercepting chip architectures mid-flight before tape-out. He explains why long-horizon agents are sending demand for CPUs and storage through the roof alongside accelerators, how optical circuit switches reroute light to a spare rack in milliseconds, and why Google would rather wait on a utility than build its own gigawatt. We also cover orbital data centers and the multi-megawatt rack of 2036. Hosted by Sonya Huang, Sequoia Capital 0:00 – Introduction 1:47 – What makes a data center an AI data center 5:30 – Goodput, not FLOPS: holding yourself accountable when something fails every hour 11:52 – Doubling token capacity every six months, and where the gains actually come from 15:32 – The TPU bet: from a contrarian call in 2013 to splitting 8i and 8t 23:30 – The case for and against co-design 26:11 – Shoulder to shoulder with DeepMind: intercepting chips mid-flight 34:16 – Long-horizon agents change the shape of the data center 37:50 – Optical circuit switching and the state of networking 42:35 – Power is the binding constraint: utilities, gigawatts, and sizing a data center 49:23 – Training vs. serving clusters, seven-year-old TPUs, and open standards 58:29 – Orbital data centers and the supercomputer of 2036

Starting a company is hard. Reinventing your company for AI as a public company with quarterly earnings results is even harder. Aaron Levie has pulled off the transition with Box and offers hard-won advice for founders. The cofounder and CEO of Box argues the value isn't only in the model; it's in the bridge from a model's raw capability to the actual workflow inside a bank, a law firm, or a pharma company. That's the case for the application layer, and Box is building it: an agent harness tuned so tightly to its own file system, permissions, and search that it beats handing the raw API to Claude or ChatGPT on both accuracy and latency. Aaron explains why token subsidies from the labs can't last, why you want a model-agnostic company routing your tokens rather than the one selling them, and why coding diffused fast while the rest of knowledge work won't. (There's no "give us your GitHub" for a sales rep.) His prediction: within five years, 90% of enterprise tokens go to work no human user ever initiated. Hosted by Sonya Huang, Sequoia Capital 0:00 – Introduction 1:55 – Are application companies the hottest neolabs? 6:56 – Will the labs move up the stack? 12:34 – Box and betting the company on AI 16:50 – Hero use cases: reading a million contracts and long-running agents 18:42 – Work slop: why AI code is embraced but AI content isn't 24:08 – Building Box's agentic harness and the evals that matter 27:23 – The state of the model race 29:25 – Open-weight model adoption in the enterprise 32:34 – Memory, continual learning, and what belongs in the weights 37:29 – Box Labs and systems of record in a world of agents 44:55 – Will chat be the dominant UI for enterprise AI? 48:00 – Why coding diffused fast and the rest of knowledge work hasn't 54:31 – Staying wired in, making a company AI-first, and what it takes to win

Most public safety technology companies grow by collecting more data. Peregrine inverted the model: no sensors, no new data, a business built on connecting the data and information cities already own. Co-founders Nick Noone and Ben Rudolph received more than two dozen no's before San Pablo PD let them in the door in February 2018. Today, Peregrine powers law enforcement, emergency medical services, fire and rescue, and other services in more than 400 cities and communities globally. Nick and Ben explain their north star for data sovereignty, and discuss how Peregrine's philosophy and privacy-first approach to data access and ownership preserves individual privacy and cities' sovereignty. They walk through how AI and long-horizon agents are being deployed: a cold case agent that reproduced an exoneration detectives had reached by hand, a Wisconsin county that placed a suspect using cell records buried in 300GB of evidence, identifying threats to a synagogue, root-causing an escalation in weather-related incidents, and more. 00:00 Introduction 02:07 What Forward Deployed Engineering Means 03:58 What Silicon Valley Gets Wrong 05:23 UNHCR, Dimagi And Downstream Data Problems 08:25 Why Cities, Why Safety 10:45 Two Dozen Nos And San Pablo PD 14:19 Building Through Defund The Police 18:16 The Inversion Of The Collection Model 21:20 Data Ownership And Governance 22:57 From Nice Search To Deep Analysis 29:59 Agents Writing The Integrations 31:45 The Cold Case Agent 35:02 The Anti-Network-Effect Proposition 38:40 Facial Recognition And Hard Decisions 40:48 Technology For The Underdogs 42:54 Trusting The Individual Contributor 48:50 Ten Thousand Cities

Parag Agrawal is making a bet that goes against two decades of web search: agents will query the web a thousand times more than humans ever have, and the infrastructure built around human clicks is wrong for them. The former Twitter CEO, now founder and CEO of Parallel Web Systems, explains why Parallel treats human click data as a bug and trains on agent feedback instead. He unpacks the counterintuitive choice to ship a search agent before a search engine, building an index incrementally, and how the new Turbo product cut agentic search to 200 milliseconds. But the problem Parag keeps returning to is economic: the ad-supported internet collapses when agents show up instead of people. His fix draws on Shapley values to pay content owners for the value their pages provide agents, with real dollars reaching publishers, he predicts, within 12 to 24 months. Hosted by Sonya Huang and Andrew Reed, Sequoia Capital 00:00 Introduction 03:25 What Is Web Search 05:17 Why Start a New Index 07:52 Search Agents First 10:17 Not a Neolab 13:14 Agents vs Google Search 19:38 Inside the Search Stack 28:59 Search Multipliers With Agents 30:21 Meeting Prep Agent Workflows 31:46 Quality Cost Latency And Turbo 32:42 Are Agents Overtaking Humans 34:28 Ads Model Meets Agent Web 37:20 New Incentives For Content 40:48 Shapley Values Attribution 47:46 Parallel Web And Future Vision

Rich Sutton, who helped pioneer reinforcement learning and wrote the seminal AI essay The Bitter Lesson, has now cofounded Oak Lab with his former student Khurram Javed. Their goal: to build agents that continuously learn from their own experience rather than from us. Rich doesn't think he holds a radical view: "I'm not weird. The field is weird." He says all learning is continual, and the field is the one that needed a new name for it. Rich and Khurram argue synthetic data is "a big mistake." Their "big world hypothesis" is that the world is massively more complex than any agent or simulator, so approximations have to be updated continuously rather than frozen at deployment. Rich calls LLMs an unanticipated scientific breakthrough, but says they represent roughly a quarter of intelligence. He says catastrophic forgetting is "totally curable" with the ideas behind their continual backprop algorithm. Khurram explains why the frontier labs can't follow: they sit in a local minimum where a new paradigm gets worse before it gets better. Their target, five to ten years out, is a trillion-parameter mind that keeps learning, stays coherent, and runs on 20 watts. Hosted by Sonya Huang and Alfred Lin, Sequoia Capital 00:00 Introduction 02:10 An AI winter, a cancer diagnosis, and the move to Alberta 07:07 Writing "The Bitter Lesson," and what people get wrong 09:53 Are LLMs a positive or a negative example of it? 11:03 Synthetic data is "just a big mistake," and the Big World Hypothesis 18:01 AlphaGo, human priors, and why prior knowledge and learning should be friends 22:37 "Their weights never change": do LLM assistants actually learn? 26:09 Babies, squirrels, and why no animal learns by supervised learning 32:02 Rockets, imagination, and where paradigm shifts come from 36:42 The Alberta Plan and its 12 steps 38:53 Catastrophic forgetting and the cure 43:43 Oak's biggest ambition: a self-maintaining mind 47:56 Why the big labs are stuck in a local minimum 49:13 If everything goes right: LLMs, many minds, and hiring

Most people treat biology as a bespoke, messy science. Josh Meier and Matt McPartlon, co-founders of Chai Discovery, treat it as an engineering problem. They make the case that drug design obeys the bitter lesson: scale data, models, and compute, and the model can learn what a hand-built pipeline simply couldn't capture. The results are concrete: Chai-2 pushed de novo antibody design from a sub 0.1% hit rate to 16%, turning a needle-in-a-haystack search into something more like designing a key to fit a lock. Josh argues, counterintuitively, that biology is more verifiable than code, and explains why the goal should be more lab experiments, not fewer. Their bet: a design suite that collapses drug discovery from nine months to nine days, and arms the pharma industry rather than competing with it. Hosted by Pat Grady and Sonali Singh, Sequoia Capital 00:00 Introduction 01:52 From Discovery to Design 03:25 Protein AI Breakthroughs Timeline 06:04 Why Start in 2024 10:13 Diffusion Models Intuition 11:41 Building the Avengers Team 15:22 Hit Rates and Scaling Laws 25:01 Molecular CAD Vision 25:24 Faster Design Loops 26:32 Future Drug Discovery 28:37 Platform Business Model 31:14 Partnering Reality Check 33:44 Data Flywheel Explained 37:16 Staying Ahead at Scale 39:44 Culture and What's Next

Jerry Tworek led reasoning at OpenAI, convinced that scaling reinforcement learning was the path to AGI. Rohan Anil co-led Gemini pre-training and built the Shampoo optimizer. Now they've teamed up at Core Automation on a contrarian premise: the transformer has carried us as far as it can, and the bottleneck to smarter systems is no longer scale — it's the architecture itself. The missing capability is continual learning, models that adapt at test time, which transformers can't do. In-context learning taps out fast (Codex needs compacting after ~20 minutes) and fine-tuning invites catastrophic forgetting. Rohan argues pre-training and RL should be optimized end-to-end, and that transformers spend computation inefficiently. They lay out why the largest labs won't chase alternatives while locked in the coding-agent race, and why building the world's most automated lab starts with automating kernel generation—the one place frontier models still lose to a high-taste human. Hosted by Sonya Huang and Pat Grady, Sequoia Capital

Factory started building fully autonomous coding agents in April 2023, two years before enterprises were ready. Matan Grinberg now says this is indistinguishable from being wrong. The Factory co-founder and CEO explains how the company survived its "journey in the desert," including the decision to hand nearly all of its revenue back to customers when the product wasn't making developers obsessed. Matan makes the contrarian technical case that a model-agnostic harness beats the model-and-harness co-design that labs like OpenAI and Anthropic favor, because exposing a harness to many models keeps it from overfitting to any single one. He argues open-weight models like GLM will capture the majority of tokens by staying one generation behind the frontier at a fraction of the cost, and that CIOs will soon justify every incremental token the way they justify headcount. Looking ahead, he predicts 90% of coding tokens will run asynchronously—the "dark factory" where software builds itself. Hosted by Sonya Huang and Pat Grady, Sequoia Capital