Dr. Joni Watson speaks with Ann Louise Puopolo, a venerated safety professional and former VP of enterprise patient safety at CVS Health. Anne Louise shares her extensive experience in patient safety, emphasizing the symbiotic relationship between quality healthcare outcomes and patient safety. She explores the crucial roles of data analysis, risk management, and creating a culture of transparency and accountability. Insights into medical malpractice and the importance of peer support programs are discussed, alongside strategies for engaging front-line staff in workflow design. Anne Louise also addresses the ongoing challenges in healthcare, such as workplace violence and the imperative of supporting healthcare workers.