In this episode I try to share what I have learned about Germinal Centers (GC) - a part of your immune system that allows B cells to selectively mature into producing the best-fitting antibodies. The GC are an important part of the affinity maturation process wherein B cells are provoked to mutate into a wide variety of options, some of which will fit better than others to the spike protein. I close with some thoughts about what this might mean for people considering vaccination vs natural disease with respect to durable immunity. There's a surprise guest at the end...Cell, Oct 2020 - GC weakened in severe COVID-19 Immunity, Dec 2020 - GC and mRNA vaccines