In this talk, Dr. Kharrazian reviews the many pathways through which inflammation impacts the body. In a nutshell, inflammation is like throwing fuel onto the fire. Wherever you already have issues with pain or inflammation, an inflammatory diet and other triggers will simply worsen those conditions. Aging is another consideration — as we age we naturally become more prone to inflammation due to the gradual decline of the body's antioxidant systems. You will learn about these mechanisms, how to find triggers of inflammation, and anti-inflammatory and antioxidant strategies to mitigate the damage.Find out more on drknews.com.[00:00:24] . So now, when you're looking at what causes inflammation, the first answer is an imbalance of free radicals and antioxidants. Inflammation can also be caused by an imbalance of our microbiome. Systemic inflammation caused by imbalance of free radicals/antioxidants and microbiome.[00:23:37] Antioxidants and anti-inflammatories protect body from free radicals; various compounds have different mechanisms; common ones include vitamin E, fish oils, antihistamines, resveratrol, turmeric, vitamin A, vitamin C, and liposomal glutathione.[00:26:06] C reactive protein is a blood biomarker used as a general marker for inflammation. High levels (over 3 or 5) can indicate disease, but not all inflammation increases production of CRP.[00:30:21] Insulin resistance causes chronic inflammation, immune response, free radicals and oxidative stress, leading to tissue damage.[00:32:30] Exercise can cause inflammation in those with chronic conditions, so they should work their way up, clean their diet, and take antioxidants.[00:34:45] Neurogenic inflammation triggered by stress, lack of sleep and unhealthy relationships.[00:37:52] Turmeric has active curcuminoids that have an anti-inflammatory effect; people have different cost-benefit ratios for using it; other anti-inflammatory compounds may be more effective for some people.[00:43:36] Gut Puzzle program teaches diet, lifestyle, and understanding of gut dysfunctions to treat sibo and other conditions.[00:46:41] Cortisol has a bi-directional effect on inflammation, health, and gut; acute stress is anti-inflammatory, chronic stress is catabolic and can create inflammatory responses.[00:51:09] Gut motility problems, such as those caused by inflammation and neurodegenerative diseases, can lead to chronic constipation. Gut Health Puzzle program teaches how to address these issues.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

The concept of small intestinal bacterial overgrowth is one that is becoming very popular but also widely misunderstood and confusing. Compared to the large intestine, there are very few bacterial species in the small intestine. When SIBO happens, the bacteria in the large intestine translocate to the small intestine causing fermentation, bloating, and excessive distension. Foods that commonly trigger SIBO symptoms include fibrous foods, sugar, sweeteners, prebiotics, and fermented foods.However, not all bloating and distension is SIBO. This is where confusion comes from. In this episode, I discuss how to tell it really is SIBO, SIBO tests, what causes it, and what to do about it.Find out more on drknews.com.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Chronic gut health problems some people face can stem from brain-related dysfunction. Key groups of brain-related problems can cause gut problems: neurodegeneration, traumatic brain injury, neurological autoimmunity, and neurodevelopment disorders.In this episode, I discuss these key categories of brain-related problems and how they affect the gut through the vagus nerve as one of its functions is activating the gastrointestinal tract. Find out more on our website at Drknews.com.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Glutathione is the body’s master antioxidant, meaning it helps protect your cells from pathogens such as viruses. It also lowers the risk of developing food and chemical sensitivities, and is a powerful ally in managing autoimmunity and preventing tissue destruction.Unfortunately, environmental toxins, chronic stress, unhealthy diets, inflammation, medications, alcohol, aging, and many other factors continually deplete glutathione. Making sure your glutathione status is strong and reducing glutathione depletion can play a profound role in immune resilience to viruses and in managing autoimmune disease, inflammation, chemical sensitivities, food sensitivities, and other chronic health issues.In this podcast, Dr Kharrazian discusses what glutathione really is, and the supplements and precursors that come in many different forms. How do you know which one to take? How much should you take? How can you tell it's working?Find out more on our website at Drknews.comSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

A complete thyroid panel can tell you about thyroid function, feedback loops, and how thyroid hormones are converting. The main thyroid markers are TSH, the pituitary hormone-stimulating gland, and T4 and T3, which are produced by the thyroid gland. Thyroid hormones are bound to proteins called thyroid hormone-binding globulins. Those are total T4 and total T3. T4 is converted to T3, which also makes reverse T3. At some point, thyroid-binding globulin levels release the T3 and T4, which then become free T3 and free T4. You can have defects all along these pathways, which I discuss in this podcast.To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

If you have hypothyroidism, the first question you have to ask yourself is how long did it take to finally get diagnosed? Most people do not receive a diagnosis immediately after symptoms appear. What happens to most people instead is they struggle with symptoms for months or years: Hair loss, constipation, cold hands and feet, fatigue – symptoms get worse and worse and they keep developing new ones. Yet their doctor says their lab tests are normal until their thyroid function is bad enough to receive a diagnosis or they find a knowledgeable doctor. By then their body has been deprived of thyroid hormone for quite some time. One problem that can lead to is gallbladder sludge and gallstones. Gallbladder congestion in turns leads to poor absorption of fat-soluble vitamins such as vitamin D, which cascades into other health problems.This is one reason gallbladder issues are so common among hypothyroid patients.To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

If you have hypothyroidism, there is a greater than 90% chance that Hashimoto's, an autoimmune disease, is the cause of your hypothyroidism. If you have one autoimmune disease, then you probably have other autoimmune diseases.Researchers once believed that autoimmunity was an isolated dysfunction of the gland from an autoimmune response that had no other systemic effects.Current research shows autoimmunity stems from immune dysregulation and loss of immune tolerance – meaning the immune system loses tolerance to foods, chemicals, and its own body tissue.This means that any tissue in the body is vulnerable to autoimmunity, and that the mechanisms that set into motion one autoimmune disease can lead to another.The goal is to regulate immune function and drive autoimmune expression into remission, which will lower your risk of developing future autoimmune diseases.You do this by identifying your triggers and following strategies that dampen inflammation and boost immune *regulation.* How you do this makes up the bulk of my content on my site (drknews.com) and in my books (on amazon).To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

The two main antibodies to screen for Hashimoto’s are thyroid peroxidase (TPO) antibodies and thyroglobulin (Tg) antibodies. It’s important to check both because either one can be elevated, although TPO is more commonly elevated. An important thing to understand about thyroid antibodies, which are used to screen for autoimmune Hashimoto’s hypothyroidism, is that the antibody itself isn't directly related to the severity of the disease. The T cell immune response, which attacks tissue tagged by antibodies, also plays a role. To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Why is it so difficult to get diagnosed with hypothyroidism and Hashimoto's in the current healthcare system? As a healthcare practitioner, it's pretty rare when a patient says, "Yeah, I had symptoms and right away they diagnosed me with hypothyroidism.” Several reasons go into why it’s hard to get a hypothyroidism diagnosis:• The disease comes on slowly so it can go misdiagnosed for years.• Doctors do not screen for thyroid antibodies that would catch early Hashimoto’s because it’s not covered by insurance or considered standard of care.• Conventional lab ranges are too wide.• TSH can fluctuate up and down and may be normal at the time of the test.• HMO doctors are assessed based on how much each of their patients cost and avoid tests they feel are unnecessary.To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode Dr. Kharrazian discusses the commonly asked question, which thyroid hormone replacement works best? The important thing to understand is there is not one optimal thyroid replacement. Issues exist with all types of replacement depending on the person and their unique situation and needs. Each person must figure out what their challenges and needs are and which thyroid hormone is most appropriate for them.To learn more, visit the site or the online Hashimoto's: Solving the Puzzle course page.Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.