Dr. Valerie Cacho (@drvalsleepgal) joins me for another countdown of the Top 10 Sleep Threats, and her list asks a question we should all be asking more often: Have we actually figured out what is disrupting someone’s sleep? From peptides marketed as cures to the assumption that a woman’s fatigue is simply part of being a working mom, Valerie takes aim at the shortcuts that can delay an accurate diagnosis. In this episode we will: Examine what the research does—and does not—say about peptides...
Sep 28
50 min
A courtroom, an insurance formula, and a supermarket receipt don't usually belong in the same sentence — but together they answer the question this episode is built around: what does a bad night's sleep actually cost, in dollars, tonight? Not the economy. You. We take the number everyone quotes and can't act on — sleep deprivation costs the U.S. $411 billion a year — and rebuild it from the ground up using the data that was actually measured on individuals, not GDP models. In this episode we ...
Sep 21
36 min
A few days ago, we did an experiment to see how well AI could interview me about sleep. In this bonus episode, I reveal the original attempt which was a bit all over the place. The interview was much more personal and strange which we corrected by adjusting the prompt in the "official" episode, but I thought it might be funny to share the trial run. In this episode we will: -Debate how much of my career success can reasonably be attributed to my looks -Discuss my questionable resemblanc...
Sep 16
32 min
What happens when the interviewer knows nearly everything you have said publicly and has zero fear of challenging or offending you? In this unusual episode of Sleep Unplugged, I turn over all control of the podcast to AI and let it ask the questions and dictate the program. The result is a surprisingly candid conversation about certainty, contradiction, expertise, and what an algorithm might see when it examines a career devoted to sleep. In this episode I (or we?) will: Turn the microphone a...
Sep 14
28 min
A Massachusetts courtroom just produced something that almost never survives into public record: a near-complete paper trail of one woman's psychiatric care in the three months before catastrophe. Her diary, her phone notes, and the testimony of every provider who tried to help her sleep all lead to a central question: what actually happens when insomnia and psychiatric illness feed each other, and how thin is the system supposed to catch it before it breaks? In this episode we will: Walk thr...
Sep 7
48 min
Dr. Alison Kole is taking on sleepmaxxing, ChatGPT, and the sleep-industrial complex in her Top 10 Sleep Threat list. In this episode we will: Explore why patients sometimes arrive at the sleep clinic with their story and diagnosis already writtenLook at the fear of sleep studies, sleep apnea diagnoses, and outdated ideas about CPAPAsk why CBT-I remains underused despite being the gold-standard first-line treatment for chronic insomniaConsider why better sleep requires thinking beyond the bed...
Aug 31
43 min
Nobody blinks when a doctor says you'll be on blood pressure medication for the rest of your life. Say the same sentence about an antidepressant, or Zepbound, and responses are quite different. This episode digs into deprescribing, the fast-growing clinical movement around when and how to stop medications, and asks why some "forever drugs" get a cultural pass while others get moralized. In this episode we will: Separate the real clinical debate around antidepressant tapering from the online d...
Aug 24
43 min
Our current gig economy did not just create new jobs, it expanded a whole new category of night worker, from rideshare drivers to online freelancers to overnight fulfillment teams. Today (or tonight rather), our bodies are struggling to make the switch. In this episode we dig into what that circadian resistance actually costs your heart and metabolism long-term, and the handful of interventions that can actually shift it. In this episode we will: Break down why 22 of 30 permanent night nurses...
Aug 17
31 min
Nasal strips have been a fixture in pharmacy aisles and on athletes' faces for decades, sold on the promise of easier breathing, but the peer-reviewed evidence often tells a different story than the packaging does. We put nasal strips and internal dilators through the RCT wringer and sort out what these devices can and can't actually do, from your bedroom to the finish line. In this episode we will: Break down what the highest-quality evidence — a 2026 meta-analysis of 17 studies and nearly 5...
Aug 10
24 min
Ten million prescriptions a year, and most of them aren't for what the drug was built to treat. Seroquel started life as an antipsychotic — engineered to quiet psychosis, not close your eyes. Somewhere along the way it became one of the most common "off the record" sleep aids in America, riding on a side effect nobody set out to sell. The evidence behind that shift is thinner than most people assume — and Seroquel isn't the only drug doing this. In this episode we will: Trace quetiapine from ...
Aug 3
41 min
Load more