Semaglutide works for weight loss but at what co$t? BOARD CHANGER- New gonorrhea guidelines Diabetes drugs are expensive for our patients and we can't forget that. Children find it hard to tell what facial expression you are giving when you have a mask on! https://www.nejm.org/doi/10.1056/NEJMoa2032183 industry-conducted trial published in the New England Journal of Medicine. Researchers randomized nearly 2000 participants without diabetes who were either overweight with at least one weight-related comorbidity or obese to receive All2.4 mg subcutaneous semaglutide or placebo weekly for 68 weeks. mean bmi 38. weighing at 105 lbs. Mean weight loss was significantly greater with semaglutide than placebo (15% vs. 2%), as was the percentage of patients losing >5% of body weight (86% vs. 32%). difference is 31lbs-- over 68weeks or 16 months.. the drug cost 734$ per month. that is 11,744 for treatment or 379 per pound. not worth it to me twitter and say shouldnt you have the conversation?!? BOARD CHANGER The CDC now recommends treating uncomplicated gonorrhea with a single 500-mg intramuscular dose of ceftriaxone, according to updated guidelines in MMWR. The recommendation applies to urogenital, anorectal, and pharyngeal infections. Previously, the CDC recommended ceftriaxone plus oral azithromycin. The authors note that azithromycin resistance is "an increasing concern." Nationwide, the percentage of N. gonorrhoeae isolates with reduced susceptibility to azithromycin increased from 0.6% in 2013 to 4.6% in 2018. Among the recommendations: People weighing ≥150 kg should be given a single 1-g dose of ceftriaxone. In patients for whom a chlamydial infection has not been ruled out, doxycycline 100 mg orally twice a day for 7 days is also recommended. For patients with cephalosporin allergy, an intramuscular dose of gentamicin (240 mg) plus an oral dose of azithromycin (2 g) may be considered. In cases where intramuscular ceftriaxone can't be given, an oral dose of cefixime (800 mg) is an option, but the authors note it may not be as effective. For pharyngeal gonorrhea, there are no reliable alternative therapies and test-of-cure is recommended. Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020 | MMWR BOARD ANSWER CHANGER https://news.wisc.edu/can-blocking-a-frown-keep-bad-feelings-at-bay/ remember that article back in 2010 which basically showed those people to get botox had decrease ability to defer emotions or facial expressions of others?? It was out of the university of wisconin and not they are back at it with this article---- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0243708 Children’s emotion inferences from masked faces: Implications for social interactions during COVID-19 Plos one This study took 81 7-13yr old child to see how children perceived others’ emotions as partial information about the face was presented pictures of stereotypical facial configurations associated with sadness, anger, and fear posed by male and female models. Pictures were presented in unaltered format (i.e., with no covering) or digitally altered to be (a) covered with a surgical face mask that obscured the mouth and nose, or (b) covered with sunglasses that obscured the eyes and eyebrows The primary question addressed by this study is whether masks meaningfully degraded children’s ability to infer others’ emotions “Accuracy between the faces that wore masks and shades did not differ” And that was the others conclsuions “These data suggest that while there may be some challenges for children incurred by others wearing masks, in combination with other contextual cues, masks are unlikely to dramatically impair children’s social interactions in their everyday lives” But that doesn’t tell the whole story Because when you look at the results you see that (continued)