https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792273/ Does Rewording MRI Reports Improve Patient Understanding and Emotional Response to a Clinical Report? Remember few weeks ago when I talked about 50% of people knew that broken bone and fracture were the same thing or that 1 in 5 pts couldn’t describe nonweight baring? Well this study looked o see what would happen if we changed the language in MRI reports 100pts- list of all shoulder, elbow, wrist, and hand MR images ordered in 2011 was obtained from the radiology service-- The original reports were reworded to the recommended reading level for effective health education below the eighth-grade level words such as “tear” were replaced by more descriptive and accurate words such as hole, signal change, or defect. They also used analogies (eg, gray hair, bald spot) looked at bunch of outcomes but thing I care about was understanding—did the pt understand it and they used a 10 point scale- basically asked th pts. On 1-10 scale how did you understand that report- The understanding score (mean ± SD) of all the original reports was lower (4.2 ± 2.3) compared with the reworded report (8.1 ± 2.6, p < 0.001) https://www.bmj.com/content/368/bmj.m7 Objective To assess whether an association exists between financial links to the indoor tanning industry and conclusions of indoor tanning literature. Results 691 articles were included in analysis, including empiric articles (eg, original articles or systematic reviews) (357/691; 51.7%) and non-empiric articles letters (eg, commentaries, letters, or editorials) (334/691; 48.3%). Overall, 7.2% (50/691) of articles had financial links to the indoor tanning industry; 10.7% (74/691) articles favored indoor tanning, 3.9% (27/691) were neutral, and 85.4% (590/691) were critical of indoor tanning. Among the articles without industry funding, 4.4% (27/620) favored indoor tanning, 3.5% (22/620) were neutral, and 92.1% (571/620) were critical of indoor tanning. Among the articles with financial links to the indoor tanning industry, 78% (39/50) favored indoor tanning, 10% (5/50) were neutral, and 12% (6/50) were critical of indoor tanning. Support from the indoor tanning industry was significantly associated with favoring indoor tanning (risk ratio 14.3, 95% confidence interval 10.0 to 20.4). Listen to an interview with authors that basically point out the tanning industry is doing what the smoking industry was doing for years- trying to hide and bury and throw money at it https://www.fda.gov/news-events/press-announcements/fda-approves-first-generic-proair-hfa generic pro-air—problem is the drug and the delivery system! give credit to the FDA Under the Generic Drug User Fee Amendments (GDUFA), individual companies can meet with the FDA as part of its pre-Abbreviated New Drug Application (ANDA) program to support the development of such complex generic drug products. The FDA also publishes guidance documents describing the steps the FDA recommends companies take to submit complete applications for generic drug products. In 2016, the FDA issued a revised draft product-specific guidance for proposed generic albuterol. the draft guidance provides bioequivalence recommendations. And the article that has me the most stumped is this article titled https://www.ncbi.nlm.nih.gov/pubmed/31976865 You see most of the time randomized trials of anticoagulation for atrial fibrillation exclude hemodialysis patients. However this analysis of observational studies including almost 72,000 dialysis patients sought to seek the risk and benefits of anticoagulation for those individuals with atrial fibrillation on dialysis. To me this would be no-brainer. Patient has a fibrillation makes you more prominent clot dialysis makes you more prone to clotting. Easily getting anticoagulation has to improve the rates of thrombotic events. However of the 16 studies only abixan 5 mg was associated with lower ALL CAUSE MORTALITY. Compared(continued)