Covid info https://melwy.com/blog/lancet-paper-on-chloroquine-is-overhyped-real-world-data-should-not-be-a-black-box So I couldn’t miss the largest observational study published to date on the effects of (hydroxy-)chloroquine, in 96 032 hospitalised Covid-19 patients, from an international registry comprising 671 hospitals in six continents: Surgisphere is the company that put it all together is in the end it showed not only no benefit with hydroxychloriquine but also possible harm! No transparency- they dont really say how they got their data and wont release how they got there data and no review. Lancet being this all great academic journal wont mention or say who did peer review on this article. WHAT! one of the beliefs is Lancet editor-in-chief Richard Horton. Let it slip through the cracks cause he doesnt like trump. This is well known he doesnt like trump but then to intentionally release a bad or falsified study that disagrees with a drug that president trump has openly supported is just crazy! https://www.bmj.com/content/369/bmj.m1435 Nalaxone is used to treat opiod overdose. Nalaxone can save lives- we all know that but you have to give it early because and it has to be easy to use What if we made it over the counter!!?? That would be awesome!! But in order to be available over the counter you have to have easy instructions like with motrin 1-2 pills every 6 hours not to exceed 10 pills in 24hrs. but how to do you write instructions for the common man for naltrexone—I had never thought of this will they did it in this study FDA Initiative for Drug Facts Label for Over-the-Counter Naloxone They asked 710 particpants what the instructions meant and Primary end points in our study corresponded to participant understanding of the key steps in naloxone administration as depicted on the label. The label was very easy for a medical professional, thinks like check to see if they respond. Give medication, call 911 immediately, stay with patient till EMS arrives. and mainly eveyrone got all the details correct and would only mess up because when tested on it they would say call 911 and not call 911 immediately. “Overall, the FDA found that the model label was adequate for use in the development of a naloxone product intended for over-the-counter sales.” I think this is great news cause the medication should be over the counter it is easy as not everyone who does opiods gets it from a provider but they should have easy access to the reversal medication just incase the street pill is stronger than they thought. https://www.nejm.org/doi/full/10.1056/NEJMsa1912403?query=primarycare-hospitalist https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2765248 some people need reminders- not me! You can ask my wife, I always so everything the first time I am asked and never leave my shoes in the middle of the room but that is not the case for everyone and this is no more clearly seen than in this study Effect of Patient Portal Reminders Sent by a Health Care System on Influenza Vaccination RatesA Randomized Clinical Trial randomized clinical trial of 164 205 patients served by 52 primary care practices look to see if reminders sent through a patient portal increase influenza vaccination rates Patients were randomized within primary care practices to 1 of 4 study groups (no reminder [n = 41 070] vs 1 reminder [n = 41 055], 2 reminders [n = 41 046], or 3 reminders [n = 41 034]). The primary outcome was receipt of 1 or more influenza vaccines as documented in the electronic health record, 37.5% for those receiving no reminders, 38.0% for those receiving 1 reminder (P = .008 vs no reminder), 38.2% for those receiving 2 reminders (P = .03 vs no reminder), 38.2% for those receiving 3 reminders (P = .02 vs no reminder). It appears you don’t get a lot of bang or your back with the extra reminders and just like those annoying postal cards f(continued)