This episode is a conversation with Prof Bobby Gaspar, the CEO of Orchard Therapeutics, a clinical stage biotech company developing gene therapies for severe diseases. Signal host Ursule Demael speaks to Prof Bobby Gaspar, who holds an MD/PhD and is an honorary professor of Paediatrics and Immunology at Great Ormond Street Hospital in London (United Kingdom). He has decades of expertise across academic research and biotech developing haematopoietic stem cell therapies for patients with immune deficiencies and metabolic disorders. Orchard’s lead therapy Libmedly is approved for the metabolic disorder MLD in Europe. Orchard Therapeutics Website: https://www.orchard-tx.com/about/our-story/

On this episode of the podcast, Signal hosts Michael Retchin and Ursule Demael interview Prof. Lee Cronin from Chemify. Lee Cronin is a Professor at the University of Glasgow, where he leads a research group focused on digital chemistry, automating chemical synthesis and origin of life. Lee Cronin is also the co-founder and CEO of Chemify, a startup advancing digitization and robotics for chemistry. In this episode, we discuss the idea of building a search engine for chemistry, the founding story of Chemify, and important differences between running an academic lab and a successful Series A stage startup. Lee Cronin shares how unique aspects of his personality and persistence were critical to build Chemify. Lee Cronin is an outspoken scientist, who is active on Twitter and has appeared on the Lex Fridman podcast, making for a fascinating and engaging episode!

In this episode, Nucleate Signal hosts Eric Dai and Jingyi Liu interview Dr. Trevor Martin from Mammoth Bio. They discuss Trevor's career inspirations, pivot from academia to biotech entrepreneur, the mission of Mammoth Bio, as well as lessons learned as CEO. Mammoth Biosciences is focused on discovering novel CRISPR systems that enable new possibilities for expanding biology.

In this episode, Nucleate Signal welcomes Tony Kulesa, Principal of Pillar VC and Co-Founder of Petri. Tony talks about his journey from academic science to his experiences starting a Life Sciences Incubator and ultimately joining Pillar as a Venture Capitalist. He shares the inspiration for Pillar to develop a thriving biotech ecosystem by providing founders resources, community, skills, and connections to launch founder-led biotech companies.

Summary In this episode we speak with Brian Goodman, PhD, Partner at MPM Capital who was previously an associate at flagship pioneering, co-founder of Avila biosciences, Aktis oncology, Renegade therapeutics, and Orna therapeutics. Brian talks about his scientific inspirations and the pivot from academic research to venture creation as well as the excitement and challenges that come with starting a biotech company. At MPM, Brian invests in and supports founders that are developing novel approaches to drug discovery and development.

Introducing Nucleate Signal, a celebration of the next generation of biotech leaders. In this episode, host Emmanuella Nnuji-John is joined by guest Cheri Ackerman, the co-founder and CEO of Concerto Bioscience.

In this episode, host Jingyi Liu and Sam Kessel are joined by guest Martin-Immanuel Bittner, the co-founder and CEO of Arctoris.