Vice President Vance briefs the press and defends the administration’s handling of the war with Iran. Rep. Rob Wittman (R-Va.) joins Meet the Press NOW to react to President Trump saying he will hit the campaign trail for Republicans ahead of the midterms. The lead defense attorney in the trial of Lindsay Clancy calls for one of the jurors to be removed as the judge orders the jury to continue deliberations.

The Massachusetts judge in Lindsay Clancy’s murder trial instructs the deadlocked jury to return for a fifth day of deliberations. Outgoing Rep. Dusty Johnson (R-S.D.) joins Meet the Press NOW to discuss Republicans’ odds heading into the midterm elections. NBC News’ Chief Data Analyst Steve Kornacki explains how some longtime Democratic lawmakers in Massachusetts bucked national trends by defeating younger opponents.

Rep. Lisa McClain (R-Mich.) joins Meet the Press NOW to discuss rising oil and gas prices as the U.S. launches new strikes on Iran. An anonymous whistleblower warns technical system the U.S. Postal Service built for mail in voting in flawed and untested. Rep. Seth Moulton (D-Mass.) and Patrick Roath (D-Mass.) discuss their bid to unseat longtime incumbents and their calls for generational change.

President Trump says the U.S. strikes on Iran are part of a “very limited” campaign. Oil industry expert John Kilduff explains new U.S. oil deal with Venezuela. The Supreme Court allows the White House ballroom construction to continue. Israeli settlers attacked a Palestinian woman and members of an NBC News team reporting in the West Bank amid a rise in settler violence in the occupied territory.

Kristen Welker has exclusive interviews with Sen. Ted Cruz (R-Texas) and Rep. Jim Clyburn (D-S.C.). Lanhee Chen, Adrienne Elrod, Sahil Kapur and Amna Nawaz join the roundtable.

The war with Iran hits the six-month mark. Democratic House candidate Chris Backemeyer discusses his campaign to unseat Rep. Mike Flood (R-Neb.). The Trump administration appeals an order blocking postal service regulation on mail-in ballots just 10 weeks before the midterm elections.

President Trump heads to Texas with less than 10 weeks until the midterms as his administration faces economic headwinds tied to his escalating trade war with Canada and his prolonged war with Iran. The death toll from the devastating flash floods in Nepal continue to rise as authorities continue their desperate search for survivors. Dr. Paul Offit, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia discusses the uptick in measles cases across the country.

NBC News’ Chief Data Analyst Steve Kornacki analyzes how Trump-endorsed candidates performed in South Carolina and Oklahoma primary races. Meta agrees to settle a multi-state lawsuit over social media addiction. South Carolina Democratic Senate nominee Dr. Annie Andrews discusses her campaign to beat Republican nominee Sen. Darline Graham (R-S.C.).

Iconic country music legend Dolly Parton dies at the age of 80. Canada’s Minister for U.S.-Canada Trade Dominic LeBlanc joins Meet the Press NOW after Ottawa announced retaliatory tariffs. NBC News Chief Data Analyst Steve Kornacki preview the runoff elections in South Carolina and Oklahoma.

President Trump launches a multi-front economic war threatening secondary sanctions on countries that do business with Iran while also escalating the tariff war with Canada. The debate over data centers becomes a key issue in the midterms. House Minority Leader Rep. Hakeem Jeffries (D-N.Y.) and Jared Kushner meet in private to discuss potential areas of cooperation between Democrats and President Trump.