Medicine Unboxed aims to inspire debate and medicine and to inform its culture. Medicine Unboxed is for the public, for health professionals and for all of us who will be patients one day. Despite scientific advances, medicine faces moral, political and social challenges that require the pursuit of meaning as much as knowledge. The arts and other disciplines can help to illuminate the central questions and to foster awe, empathy and humility. Our annual events - Unboxed (2009), Stories (2010), Values (2011), Belief (2012), Voice (2013), Frontiers (2014), Mortality (2015), Wonder (2016), Maps (2017)and Love (2018) - each have drawn audiences of over three hundred people. Our Soundcloud and Vimeo archives have been seen and heard by tens of thousands of people. Our speakers are writers, politicians, philosophers, scientists, musicians and performers. The events are theatrical, moving and challenging and are performances in themselves.