Psychedelics and other mind-altering substances have been used for thousands of years across the world in religious, spiritual, celebratory, and healing contexts. Despite a half century of a "War on Drugs" in the United States, there has been a recent resurgence in public interest in ending drug prohibition and re-evaluating the roles these substances can play in modern society. What can our several-thousand year history with these substances teach us about how they can be used in a modern society? What legal & cultural frameworks can be used to increase access to these substances, and what are the potential downsides of these frameworks? Ismail Ali works daily developing and implementing the legal and policy strategies that will define the next several decades of psychedelic access, and joined Long Now for a Talk that explored the deep history of psychedelics and what role they can play in our future.