Company, what they did to get started, the success and hurtles they have had, what they hope to accomplish, some of the science behind everything, and last of all, the things they are nerds about. Overall they are decent scientists. Who they are and what they are working to fix: "Erica Barnell (MD/PhD Candidate, Washington University School of Medicine) and Andrew Barnell (MBA, The Wharton School) are siblings that co-founded Geneoscopy, a startup focused on developing diagnostic tools to prevent, detect, and treat digestive diseases. Geneoscopy was founded on the belief that a noninvasive diagnostic test using human RNA biomarkers in stool samples would provide a screening alternative that could improve colorectal cancer screening compliance, facilitate early-stage detection of colorectal cancer neoplasms, and reduce morbidity and mortality associated with the 2nd deadliest cancer in the United States and the 4th deadliest cancer worldwide. However, no methodology existed to reliably isolate and preserve human RNA from stool. Over the past two and a half years, Geneoscopy has developed a nucleic acid extraction method that amplifies the human signals and degrades bacterial noise in stool. This allows for sensitive extraction of human RNA that can be used as biomarkers to noninvasively evaluate gastrointestinal health. Geneoscopy has filed three provisional patents and one utility patent to protect this technology and has leveraged it to develop a multi-target RNA biomarker panel for the detection of precancerous lesions and colorectal cancer. Geneoscopy has executed two clinical trials and tested over 340 patients, and the results of these studies have demonstrated our test’s differentiated accuracy profile, particularly for the identification of advanced adenomas (95% sensitivity). Geneoscopy is currently enrolling patients in a 1,000-patient trial to complete the development of this colorectal cancer diagnostic test, and has formed partnerships with two academic medical centers to leverage its extraction platform to develop diagnostic tests for other digestive diseases." Taken from their post on Medium. Brief synopsis of the episode: In this episode, we get into how they came up with their company, what they did to get started, the success and hurtles they have had, what they hope to accomplish, some of the science behind everything, and last of all, the things they are nerds about. Hyperlinked Show Notes Timestamps: My top 10 Favorite sections have "**" next to the time stamps. [ [ [ [ [ [ [ [ [ [ [ [ [ [