Howards Blend
Howards Blend
Howard Blend
Berberine
33 minutes Posted Dec 12, 2020 at 7:34 pm.
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This is a follow up episode to the show titled 'Controlling Blood Sugar - Diet.'

 

 

Instead of focusing on my personal experience, we cover the science of how berberine is supposed to help with blood sugar levels.

 

 

Clarifications:

 

I state that a possible benefit of berberine is to inhibit (stop) gluconeogenesis. 

 

 

I believe I interpreted the literature wrong. It used the term inhibit, but in this case inhibit means to hinder. 

 

 

So by downregulating (which I also got the definition wrong) gluconeogenic enzymes, gluconeogenesis is reduced.

 

 

Downregulation in this context is to diminish the stimulus response of the enzymes on the liver. 

 

 

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Resources:

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/

 

 

https://www.healthline.com/human-body-maps/hypothalamus#anatomy-and-function

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/

 

 

https://www.sciencedirect.com/science/article/pii/S1388198118303354#:~:text=ATGL%20mRNA%20expression%20is%20positively,tissues%20upon%20fasting%20%5B30%5D.

 

 

https://examine.com/supplements/berberine/research/#pharmacology_absorption

 

 

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/atp-binding-cassette-transporter

 

 

https://pubmed.ncbi.nlm.nih.gov/12489979/

 

 

https://examine.com/supplements/berberine/research/#safety-and-toxicology_general