On today's episode I speak with Noor Siddiqui, the founder of Orchid, a company that quantifies the genetic risks of your future children. We discuss the plunge in genome sequencing costs and why Orchid's ability to predict polygenic diseases impacts so many families compared to predicting single-gene diseases.  Noor reveals what it was like starting a company remotely during COVID, how her mother's own rare disease motivated her and what genetic privilege means. We discuss her path from doing a Thiel fellowship to teaching a crypto class at Stanford to doing genomics and AI research with Sebastian Thrun. Finally, we get into our contrarian views and why biology advances seem to provoke the strongest pushback.  Full transcript on Medium. This episode was produced by Daniel Bouza.

In the last Flux episode of 2020, Alice talks with Kevin Caldwell, founder and CEO of Ossium Health, a company building the first bank of on-demand bone marrow stem cells and developing therapeutics to treat leukemia, blood cancer, and other diseases.  Kevin discusses how he navigated his many career options and how his time with grandparents shaped his values. After graduating law school and getting degrees in physics and economics, working at McKinsey and at hedge funds, Kevin realized he wanted to have more impact and switched to life sciences.  We discuss the history of stem cell therapy and why the potential for living drugs is so exciting. Kevin shares why no-one has used bone marrow from deceased donors, and how Ossium is building the first major procurement network to enable donor and recipient matches at scale. He gets into the business model, views on the future, and the advantages of raising from both life science and traditional tech investors. Full transcript on Medium. This episode was produced by Daniel Bouza. 

Flux fandom. In today's episode Alice talks with Adam Arrigo, co-founder and CEO of Wave, a live virtual concert company. Adam has been pushing the frontier of music his whole life, from touring as a musician to designing Rockband the game at Harmonix. In 2016 Adam and Aaron Lemke founded Wave. Along the way the company has evolved and worked with artists including Imogen Heap, Kill the Noise, Tokimonsta, Galantis, Rezz, John Legend and the Weeknd. Today Wave distributes imaginative, interactive shows across platforms, from MMO games to Twitch, Youtube and TikTok. Wave just closed a Series B with Justin Bieber and J Balvin investing.  Adam gets into how the core insights around design and interactivity from the early days of VR are critical to the product today, and how he's reimagining the medium of concerts from the ground up. He explains how the pandemic has created a challenge for artists but also an opportunity for Wave to serve them. Adam discusses business models and monetization, from virtual goods to tipping. We cover trends in Asia such as the VTuber phenomenon, how companies like Riot and Epic in the U.S. are pushing the industry forward, and the new crop of creative virtual IP startups. Adam shares how the metaverse can be a beautiful and liberating place and gives advice to founders at the frontier—on how to build something that defies classification and how to find a team of passionate Avengers who align with your vision of the future.  Full transcript on Medium. This episode was produced by Dan Bouza. 

Hi from Alice and the Flux team. We hope you are safe and well.  In the latest episode I talk with Alex Bisignano, founder of Phosphorus is the second ever company to be approved by the FDA for at-home saliva testing to detect COVID-19. Alex has been on the frontlines of the pandemic in New York City. While most companies are using synthetic data, Alex and his team have collected live samples from patients in the lab. Phosphorus has been able to rapidly develop virus and antibody test products, even though that wasn't the company's prior business. Alex shares how he thinks about supply chain reliability and how they are ramping up test manufacturing. We also get into genetics as a possible predictor for COVID-19 severity, which biological pathways may play a role, and what it would look like if we had large-scale biobanks. If we are able to correctly identify who is at higher risk, what are the implications for employment and privacy policy? We get into the ethical questions around mandatory testing and disclosure and how countries like China have responded to the pandemic. Alex also reveals how he thinks Silicon Valley may shift in its attitude towards the hard sciences and biotech. Full transcript on Medium. This episode was produced by Daniel Bouza.

Welcome back to Flux! In this episode I talk with Andy Coravos the co-founder of Elektra Labs, which is building a future of digital medicine that's data-driven and secure. Recently we’ve seen an explosion of wearables and sensors in healthcare. How accurate are these monitoring tools? How secure are they from hackers? Elektra is cataloguing these distributed devices and has created benchmarks for pharmaceutical companies, doctors and device makers. We're also now seeing the advent of digital therapeutics such as video games that help treat ADHD or PTSD. Is the FDA equipped to respond to these changes? How will doctors and pharmacies prescribe digital medicine?    Andy shares her thoughts on the FDA and what she feels is the balance between proper regulation and advancing progress. She discusses what wearables she personally is comfortable using and why a Hippocratic Oath for devices is important. Andy tells me about her family of tinkerers and inventors, why she finds meditation critical, and how she got the courage to jump from private equity to startups.    Full transcript on Medium. This episode was produced by Daniel Bouza.

In this episode we try out a new format. I talk remotely with LaTurbo Avedon, an online avatar who has been active as an artist and curator since 2008. Her responses have been run through a speech synthesizer.   Recently we've seen a wave of next-gen virtual stars rise up, from Lil Miquela in the west to pop-stars like Kizuna AI in the east. As real-time avatar representation becomes more accessible, what emergent behaviors will we see and what will our virtual relationships look like? LaTurbo was early to exploring these questions of identity and experimenting with telepresence. She has shape-shifted across media types, spending time in everything from AOL and chat rooms, to MMOs, virtual worlds and social media platforms. She shares her thoughts on how social networks have breached our trust, why a breakup is likely, and how users should take control of their data. We get into the rise of battle royale gaming, why multiplicity of self is important, and how we can better express agency and identity online. This episode was produced by Adriene Lilly. Full transcript with links on Medium.

In this episode I talk with Matt Cauble the co-founder of Kin Euphorics, a functional beverage company that aims to reduce stress — “all bliss, no booze.” Matt was previously a co-founder of Soylent and he shares tales from the company’s early days, describing how they made one of the largest pivots in YC history from building software-defined radios to meal-replacement shakes. He explains why Soylent resonated and we get into co-founder Rob Rhinehart's latest interest in space settlement and the Mars industry event he hosted in the Mojave. Matt shares why he is now interested in wellness, how he's applying lessons from Soylent to building the Kin community, and why strong companies often look like new social movements. We get into the product’s formula, which includes nootropics and adaptogens, and what it means to challenge a ritual as ancient as alcohol.

Eric Marcotulli is the co-founder of Elysium, a life sciences company developing consumer-facing health products based on aging research. Elysium's first product is Basis, a supplement that increases NAD levels and activates sirtuins, boosting cellular health and longevity.    In the latest episode of Flux we discuss why longevity companies like Sirtris Pharmaceuticals failed, which was initially bought for $720 million in 2008. Eric explains why going direct to consumer is the best strategy and what the current Basis user base looks like. He shares what its like working with eight nobel laureates on his science advisory board and how they decide what product research to pursue. He gets into the importance of bringing peer review rigor to the category, how he plans to build consumer trust, why cellular senescence is a particular area of interest, what his personal health routine is and how he thinks about the singularity. 

In the this episode I sit down with Isaac Cohen (Cabbibo), a fascinating creator at the forefront of VR and AR who has released a number of apps and experiences that push the boundaries - you can find some of his pieces on Steam. He has a background in physics and interface design, previously worked at Leap Motion, and has been an artist in residence at Unity and Adobe. Isaac shares his views on why realism in VR is the wrong approach and how developers need to approach it in a transformative rather than a derivative way. He describes the ARkit workflow, how he thinks about using AR to give users agency, and why emotional efficiency is important in computing. He gets into some of the UX insights he's picked up along the way, which creators inspire his work, what today's corporates can learn from the long-term research done at places like Xerox PARC, and the role artists play in pointing them towards the right questions. Full transcript on Medium.   This episode was produced by Adriene Lilly and Allison Behringer. 

Alban Denoyel is the CEO of Sketchfab, a 3D hub to publish, share, buy and sell 3D, VR and AR content. We discuss the history of the business and what the company has learned from Youtube and why they are pursuing a distributed content strategy. Alban shares how power creators are using the platform to monetize content, the powerful role 3D plays in cultural heritage, and the importance of figuring out standards and formats in 3D. With Sketchfab crossing 1 billion cumulative page views, Google's Poly turning one, and Microsoft's Remix 3D turning two, it's an interesting moment to reflect where we are in the trajectory of the 3D web.