Episode 23 of CRAMSURG - Clinical Reasearch Appraisal and Methodology for Surgical Trainees. The paper for discussion is Sixty-Day Mortality of Patients With Metastatic Colorectal Cancer Randomized to Systemic Treatment vs Primary Tumor Resection Followed by Systemic Treatment The CAIRO4 Phase 3 Randomized Clinical Trial JAMA surg Oct 2021. Brought to you by CRAMSURG www.cramsurg.org.