In March 2020, the World Health Organization officially declared the SARS-COV-2 infection outbreak a global pandemic, spurring one of the greatest public health crises and education efforts in recent history. And while there have been several victories in the battle against this global pandemic, such as the widespread adoption of telehealth and the development of COVID-19 vaccines, many questions still remain. That’s why our COVID-19: On the Frontlines series features infectious disease physicians and public health education experts from around the world to bring you the latest news on COVID-19 vaccines, clinical practice updates, and research from clinical trials so that we can continue to keep our patients safe amid this global pandemic and beyond.