![[Bonus] When a Last Resort Antibiotic Fails: The Drugs That Shape Us](https://cdn-images.podbay.fm/eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJ1cmwiOiJodHRwczovL3N0b3JhZ2UuYnV6enNwcm91dC5jb20vZTQ2bG9zZG9wYzdmcnRiczR3MmQzODY1dXV5dT8uanBnIiwiZmFsbGJhY2siOiJodHRwczovL2lzMS1zc2wubXpzdGF0aWMuY29tL2ltYWdlL3RodW1iL1BvZGNhc3RzMjExL3Y0LzhjLzg4L2I4LzhjODhiODE2LTczNzAtM2MxNy0zZjU4LTU5ZTE3MzJhMmFjYy9temFfMTQwMzA5MTYwMzgzNzk3NDIyMDkuanBnLzYwMHg2MDBiYi5qcGcifQ.D8zT3FzFwpl2CAsdkydDsGCD7kCCD2YH7pVpA-KSkaU.jpg?width=200&height=200)
On this bonus episode we answer a listener's question about antibiotic resistance arising from agriculture by diving into the story of colistin, an antibiotic that is used as a last resort treatment. When colistin resistance was first reported in animals and humans, the public health community was understandably panicked, prompting governments to take action to regulate its use. Transcripts and episode sources at acs.org/chainreaction
Sep 17
14 min
If you’re on social media, you may feel bombarded by influencers promoting peptides for a range of ailments so broad it almost seems like a brand-new trend. But peptide-based therapies actually date back to 1922, when insulin was first administered to treat diabetes. But it wasn’t until semaglutide (better known as Ozempic) entered the market that peptides truly captured public attention. In today’s episode, we explore how what chemists and other scientists learned from insulin paved the way ...
Sep 3
41 min
In the late 1950s, a tuberculosis drug was repurposed as the world’s first antidepressant. Then the selective serotonin reuptake inhibitor (SSRI) Prozac ushered in a new era of antidepressants. Today SSRIs are some of the most widely prescribed drugs in the country, but gaps still exist in our biological understanding of mental health, the overall efficacy of antidepressants, and predicting serious side effects. In response, some scientists and physicians are turning to different classes of d...
Aug 27
56 min
The discovery of sex hormones in the 1930s led to the development of female birth control, a widely used class of drugs that reshaped cultural norms surrounding fertility and bodily autonomy. But contraception remains largely the responsibility of women. On today’s episode: the evolution of birth control and the future of male contraception. Transcripts and episode sources at acs.org/chainreaction
Aug 20
40 min
Through a few serendipitous discoveries, antibiotics changed the course of history by turning deadly infections into manageable sicknesses. But it didn’t take long for bacteria to begin outsmarting these wonder drugs. On today’s episode: The fascinating world of antibiotics and the efforts to tackle antibiotic resistance, including using AI to come up with new drugs that will only become more essential. Transcripts and episode sources at acs.org/chainreaction
Aug 13
50 min
You’ve likely relied on a drug at one point or another, whether it be a prescribed medication or something over the counter. The upcoming miniseries of Chain Reaction explores the history, impact, and future of major drug classes, including antibiotics, birth control, antidepressants, and GLP-1s. Margot and Sam will chat with experts about the history and scientific breakthroughs behind these medicines and the ongoing research that could shape the next generation of drugs. Transcripts a...
Aug 6
1 min
This bonus episode continues the celebration of the American Chemical Society’s 150th anniversary by spotlighting two remarkable ACS presidents whose work helped shape public health in very different ways. Hosts Margot and Shane trade stories about these pioneering chemists. Harvey Wiley, ACS president in the 1890s, investigated dangerous food additives like formaldehyde and borax and presided over the infamous “Poison Squad” experiments. He was part of the impetus behind the “Wiley Act...
Jul 23
18 min
To cap off this special #ACS150 miniseries, we chat with chemistry educator, science communicator, and social media creator Kim Hilton — better known as Chemical Kim (follow @chemicalkim). Kim reflects on her unexpected path into teaching, from struggling to understand chemistry as a college student to becoming a professor who has spent three decades helping others discover their place in STEM. The conversation explores Kim’s passion for outreach, from creating hands-on science experiences fo...
Jul 9
36 min
Space is the place . . . for chemistry! ACS president-elect Chris Bodurow and three colleagues chat about the role of chemistry in space exploration and how they ended up working in such an exciting field. Luke Roberson, Ken Savin, and George Rodriguez highlight the expanding space industry, the technologies that chemistry has enabled in space, and how chemistry might change the industry in the future by, for instance, enabling long-term life-support systems. Across all conversations, one thi...
Jul 2
27 min
ACS president Rigoberto Hernandez invites colleagues to speak about mentorship, communication, and the human side of science. One of Rigoberto’s former students, Ashley Ringer McDonald, talks about the power of multi-directional mentorship and the importance of nurturing growth and confidence in students. Michelle Francl and Rigoberto discuss the evolving role of theoretical chemistry, the need to balance basic and applied research, and the importance of communicating science in accessible, e...
Jun 25
28 min
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