Single-nucleotide polymorphisms and &nbsp;copy-number variations (CNV’s) &nbsp;result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in &nbsp;the accumulation of chromosomal variation.
Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 &amp; RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins.
<ul>
 <li>FEBS J. 2017 Jun; 284(11): 1590–1605.</li>
</ul>
 

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Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry

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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.