The New England Journal of Medicine (NEJM) Weekly Audio Summary RSS feed. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
Featuring articles on an antisense oligonucleotide for SOD1 ALS, the treatment of familial ALS with a viral vector, angiogenesis and Covid-19, a multifactorial strategy to prevent serious fall injuries, and nemolizumab for atopic dermatitis; a review article on cervical spondylosis; a case report of a homeless man with Covid-19; and Perspective articles on social prescribing; on ensuring choice for people with kidney failure; on disease control, civil liberties, and mass testing; and on coronavirus and the Navajo Nation. Supplement to the New England Journal of Medicine, Vol. 383, No. 2.
Featuring articles on allopurinol and kidney function in type 1 diabetes, the effects of allopurinol on progression of chronic kidney disease, the effect on patient safety of eliminating extended resident physician shifts, higher-dose hydroxyurea for sickle cell anemia, and black patients and white patients with Covid-19; a review article on salicylate toxicity; a case report of a girl with severe psychological distress after family separation; and Perspective articles on physician burnout; on kinder, gentler dementia-friendly Alzheimer's care; and on how medical education is missing the bull's-eye. Supplement to the New England Journal of Medicine, Vol. 382, No. 26.
Featuring articles on presymptomatic SARS-CoV-2 in a nursing facility, olaparib for metastatic prostate cancer, PTEN defects from WWP1 activation, liraglutide for adolescents with obesity, and label testing for over-the-counter naloxone sales; a review article on acute-on-chronic liver failure; a case report of a man with Covid-19 and acute kidney injury; and Perspective articles on harnessing our humanity, on sharing health data and biospecimens with industry, on flattening the curve for incarcerated populations, and on blood ties.
A 50-year-old, previously healthy man presents to the ED with 2 days of worsening dyspnea. He had fever, cough, and fatigue during the week before presentation. He appears acutely ill. The body temperature is 39.5°C, heart rate 110 beats per minute, respiratory rate 24 breaths per minute, and blood pressure 130/60 mm Hg. The oxygen saturation is 87% while the patient is breathing ambient air. The white-cell count is 7300 per microliter with lymphopenia. Chest X-ray shows patchy bilateral opacities in the lung parenchyma. An RT–PCR assay detects the presence of SARS-CoV-2 RNA in a nasopharyngeal swab. How would you evaluate and manage this case? Full-text recordings of Clinical Practice articles can be found at NEJM.org.
Featuring articles on vericiguat in patients with heart failure, anti-PD-L1 and anti-VEGF in hepatocellular carcinoma, Lactin-V to prevent recurrence of bacterial vaginosis, rivaroxaban or enoxaparin in nonmajor orthopedic surgery, and dopaminergic precursor cells for Parkinson’s disease; a review article on transient ischemic attack; a case report of a man with hyponatremia and involuntary movements of the arm and face; and Perspective articles on facing Covid-19 in Italy, on the state of cannabis research legislation in 2020, on Medicare Part D and insulin affordability, and on the day a physician’s gut feeling led her astray.
A 73-year-old man with hypertension and chronic obstructive pulmonary disease calls to report that he has had a fever and a dry cough for the past 2 days. He notes that his shortness of breath has worsened. His medications include losartan and inhaled glucocorticoids. He lives alone. How should he be evaluated? If he has Covid-19, the disease caused by SARS-CoV-2, then how should he be treated? Full-text recordings of Clinical Practice articles can be found at NEJM.org.