On this episode, I discuss the pharmacology of commonly used stimulant laxatives like sennosides and bisacodyl.
Stimulant laxatives "stimulate" the GI tract smooth muscle which helps propel fecal material out of the body and thus helping to relieve constipation.
Patients who are having diarrhea and are unsure of what medications they are taking should have their regimen assessed for these medications.
Chronic opioid therapy is a situation where chronic stimulant laxative therapy may be used.
Stimulant laxatives have very few drug interactions. However, bisacodyl effectiveness can be reduced by the use of antacids like calcium carbonate.