Pioglitazone Pharmacology
Published March 21, 2019
|
12 min
    Download
    Add to queue
    Copy URL
    Show notes
    On this episode, I cover pioglitazone pharmacology. The primary mechanism of action with pioglitazone is that it is an agonist at Peroxisome Proliferator Activated Receptor Gamma receptor. This improves insulin sensitivty in the periphery.



    Two common side effects exist with pioglitazone. This drug can cause weight gain and also contribute to edema.



    Pioglitazone has a boxed warning and is contraindicated in patients who have symptomatic heart failure.



    There are a few potential interactions with pioglitazone. Trimethoprim and gemfibrozil can inhibit the breakdown of pioglitazone.



    A couple of advantages of pioglitazone include that it is generic (inexpensive) and that it is dosed once daily.
      15
      15
        0:00:00 / 0:00:00