Hydralazine works as a direct vasodilator. It primarily works on the arterioles versus the venous system.
Hydralazine can cause a unique adverse reaction. It can cause a Lupus type syndrome that can result in fever, myopathy and symptoms that mimic arthritis.
I discuss drug interactions with hydralazine and how you need to be aware of certain medications that can have additive effects and also those that can oppose the effects of the drug.
One of the downsides to using hydralazine is that patients don't like to take it as often as it requires. It is typically dosed three to four times per day.
Orthostasis is a risk with any drug that reduces blood pressure and hydralazine is no different.