Metabolism Made Easy
Metabolism Made Easy
A J Ghalayini, Ph.D.
Insulin: Activation of Lipid Synthesis
2 minutes Posted Oct 29, 2025 at 6:04 am.
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Insulin will activate fatty acid synthesis, triacylglycerol synthesis and cholesterol synthesis by dephosphorylating two key enzymes: acetyl CoA carboxylase and HMG CoA reductase. Insulin will upregulate lipoprotein lipase, increasing uptake of fatty acids from circulating chylomicrons into various tissues. Glucose will provide both precursors for triacylglycerol synthesis and fatty acid biosynthesis.