Veterinary Vertex
Veterinary Vertex
AVMA Journals
When the Tests Disagree: The Diagnostic Gap Between Cytology and Histopathology in Canine Splenic Masses
15 minutes Posted Jun 23, 2026 at 8:00 pm.
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Why Splenic Masses Need Better Answers
What 55 To 67% Agreement Means
Why Cytology Misses Dangerous Tumors
When Monitoring Beats Splenectomy
Talking Through The Gray Zone
Surprises, Next Studies, Closing
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Send us Fan Mail A splenic mass shows up on ultrasound and the question hits like a brick: benign or malignant? We go straight at the uncomfortable truth behind canine splenic cytology. Even when splenic FNA feels like the “do something now” step, the match between cytology and histopathology is only moderate, and that has consequences for how we advise families, schedule rechecks, and decide when splenectomy is the safest path. We talk with Drs. Janet Grimes and Matthew Aluisio about what t...