Send us Fan Mail We sit down with Dr. Lynn Pezzanite to explore a promising angle on aging-related equine osteoarthritis (OA): cellular senescence, the pro-inflammatory state where cells release a senescence-associated secretory phenotype (SASP) that can amplify damage inside tissues over time. We walk through why horses are such a valuable One Health model for osteoarthritis research and why this team compared synovial fluid cells from the joint with peripheral blood mononuclear cells from ...