Veterinary Vertex
Veterinary Vertex
AVMA Journals
Bumped-Kinase Inhibitors: A New Path Toward Treating EPM in Horses
13 minutes Posted Dec 20, 2025 at 6:00 am.
Sponsor And Show Introduction
Meet The Hosts And Guest
Why EPM And Horses Matter
Isabella’s Path Into EPM Research
What Are Bumped Kinase Inhibitors
Selectivity Via The Gatekeeper Concept
Apicomplexan Biology And CDPK1
Opportunities In Parasite-Specific Targets
Key Takeaways For Veterinarians
Drug Resistance Considerations In EPM
Broader Impacts And One Health Links
Next-Gen Leads: BKI-1708 vs 1553
Clinical Trial Hurdles And Collaboration
Translating Findings To Practice
Isabella’s Training And Motivation
Mentors And Thinking Like A Scientist
Fun Questions: Dogs And Dreams
Clinical Skill Wish: Spinal Taps
Closing And Where To Read The Paper
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Show notes
Send us Fan Mail A small structural “bump” on a molecule might be the big breakthrough EPM care has been waiting for. We sit down with researcher and clinician Izabela de Assis Rocha to unpack how bumped kinase inhibitors exploit a tiny difference between parasite and mammalian kinases to hit Sarcocystis neurona where it hurts—motility, invasion, and replication—while sparing the horse. It’s a molecular strategy with practical promise, and the conversation bridges the stall, the lab, and the ...