Informatics is a whole new approach to solving chemical problems. We talk big data, machine learning and dogs.We review a chemistry machine learning competition and talk to Professor Jeremy Frey, from the University of Southampton, about e-science.Links:- https://www.kaggle.com (data science and machine learning)- https://pubs.acs.org/doi/abs/10.1021/ci800058v (solubility challenge paper, subscription required)Credits:- Support: TMCS, EPSRC- Theme music: from "Earnest's Understanding" © 2017 Charles Ormrod