Show notes
Nathan Price, currently on leave from the Institute for Systems Biology in Seattle and Chief Scientific Officer at Thorne HealthTech, talks to JC and Andy about his data-driven approach to understanding health and predicting personal trajectories into disease as we age.03:24 What is scientific wellness?06:53 Correlates of scientific wellness15:45. Generating hypotheses18:40 Multimodal over unimodal data22:04. Biomarkers and individual disease trajectories28:00 How to intervene to maintain wellness?30:01 A new era for supplements?32:26 Single interventions versus combinations37:59 Racial background and lifestyle41:00 Digital twins, trial design and recruitment43:30 Mocktails and mojitosThe Mojito10–12 mint leaves and mint sprig 1 Oz simple syrup (50% sugar solution)2 Oz white rum 0.75 Oz freshly squeezed lime juice. ~1–2 Oz club sodaDIRECTIONS: Place the mint leaves in a shaker tin, add the syrup and gently muddle the leaves 10–12 times. Add the rum and freshly squeezed lime juice. Shake over ice for 15 seconds and double strain over fresh ice into a Collins glass. Top up with the club soda and mix gently. Slap a mint sprig to release the aromatic oils and add it as garnish. Sources mentioned in the podcastThe supposed Native American 'diabetes gene'. Newman, AS. Peace Rev. 12, 517-524 (2010)Todd Rose. The End of Average (HarperCollins, 2016). Can a biologist fix a radio? Lazebnik, Y. Cancer Cell 2, 172-182 (2002) https://www.cell.com/cancer-cell/pdf/S1535-6108(02)00133-2.pdfLancet Commission on risk factors for dementia: Livingston, G et al. Lancet 396, 413-446 (2020) https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltextPrecision Medicine Approaches for Developing Combination Therapies for the Treatment and Prevention of Alzheimer's Disease (AD) and AD-Related Dementia, National Institute of Aging, December 4-5, 2023. Khullar, D How to die in good health. New Yorker (April 15, 2024)The Mixer music “Pour Me Another” courtesy of Smooth Moves!
