The Simplicity Sessions
The Simplicity Sessions
Jenn Pike
#612: GLP Knowledge - Are They Your Best Shot? With Ashley Koff
1 hour 7 minutes Posted Sep 7, 2026 at 10:00 am.
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In this episode, I'm sitting down with Ashley Koff, registered dietitian, USA Today bestselling author of Your Best Shot, and founder of the Better Nutrition Program, for a conversation I've wanted to have for a long time. Not another "are GLP-1s good or bad" debate, but a real dive into the science, the nuance, and the questions I don't think enough of us are asking before starting one of these medications.

 

In this episode we cover:

  • Why GLP-1 and GIP are "weight health hormones," not just weight-loss drugs 

  • The receptor-site "garage" analogy that finally made hormone signaling click for me

  • Why muscle loss on these medications is a red flag, not a badge of honor 

  • The digestive-health foundation Ashley says nobody skips without consequences

  • Why HRT and GLP-1s are showing up together in new research, and what that combination might mean for women in perimenopause

  • The real reasons people come off these medications 

  • Why Ashley says walk away from anyone selling a hormone (any hormone) as "the solution"

 

Let's dive in!

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This episode is sponsored by:

  • withinUs | Use the code JENNPIKE20 at withinus.ca for a limited time to save 20% off your first order and 20% off your first subscription order

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Have a question? Send it over to [email protected] and I'll do my best to share helpful insights, thoughts and advice.