Medical Disruptor™ by Dr. E
Medical Disruptor™ by Dr. E
Dr. Efrat LaMandre PhD, FNP-C
Why Your Anxiety in Your 40s Might Not Actually Be Anxiety ft Dr. Bojana Jankovic Weatherly
37 minutes Posted May 12, 2026 at 5:49 pm.
Intro
What Is Perimenopause?
Anxiety & Insomnia
The 3AM Wake-Up
What Labs to Get
Should You Start HRT Early?
Patch vs. Oral Estrogen
How Long on Hormones?
Weight Gain on HRT
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37:56
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Show notes
If you've hit your 40s and suddenly feel like you're losing it, waking up at 3 a.m., feeling on edge for no reason, exhausted in a way that sleep doesn't fix, I want you to hear this: it might not be anxiety. It might be perimenopause.
In this episode, I sit down with Dr. Bojana Jankovic Weatherly, a double board-certified physician in internal and integrative medicine, to talk about the symptoms most of us are normalizing and most doctors are missing.
We get into why progesterone decline shows up as anxiety, insomnia, and those 3 a.m. wake-ups long before any hot flash ever does, and why so many women in this stage of life are sent home with an antidepressant or an Ambien instead of an honest conversation about their hormones. 
That's medical gaslighting, and it's stealing years of quality of life from women in their 40s. We talk about why hormone testing isn't the answer, what to track instead, and when to ask your doctor about progesterone even if you're still getting a regular period. 
If you've been told to lose some weight, try meditation, or just push through, this one is for you. You're not crazy. You're not weak. You're hormonal, and there is so much we can actually do about it.
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