The Dr. Tyna Show
The Dr. Tyna Show
Dr. Tyna Moore
The Truth About GLP-1s & Muscle Loss | SOLO
1 hour 5 minutes Posted Jun 4, 2026 at 7:00 am.
Introduction
The 40% Muscle Loss Myth
Pathologic Muscle + Metabolic Dysfunction
Why GLP-1s Are Being Misunderstood
Why Strength Training Is Non-Negotiable
Lean Mass vs Muscle Mass
How GLP-1s Affect Inflammation + Immune Health
How Obesity Damages Muscle Quality
New Research On GLP-1s + Muscle Function
Why Muscle Quality Matters More Than Quantity
How GLP-1s May Remodel Muscle Tissue
Strength Loss, Weight Loss + Performance
Bone Density + Weight Loss Concerns
Building Bone Through Strength Training
Recovery, Stress + Muscle Preservation
Sauna Recovery + Sunlighten
Glutes, Longevity + Metabolic Health
What The Latest Human Data Shows
Anabolic Resistance + Aging
What The Latest Meta-Analysis Shows
How GLP-1s May Improve Muscle Biology
Final Takeaways On GLP-1s + Muscle Loss
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Show notes
EP 264: Join my NEW community for Gen X women: ⁠https://www.skool.com/drtyna/about⁠⁠
In this episode, I'm breaking down the difference between lean mass loss and actual muscle loss, where the widely repeated “40% muscle loss” claim came from, and what the latest research really shows. I also dive into metabolic dysfunction, fatty infiltrated muscle, anabolic resistance, strength training, protein intake, and why muscle quality matters far more than most people realize.
If you've been worried about losing muscle on a GLP-1, are currently taking one, or simply want to better understand the science behind weight loss, body composition, and long-term health, this episode is for you.
Topics Discussed:
→ Do GLP-1s Actually Cause Muscle Loss?
→ The Truth About Lean Mass vs Muscle Mass
→ Where The 40% Muscle Loss Myth Came From
→ Why Metabolic Health Matters For Muscle
→ How To Preserve Muscle While Losing Weight
→ Why Strength Training Is Non-Negotiable
→ Protein, Aging & Anabolic Resistance
→ What The Newest GLP-1 Studies Reveal
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On This Episode We Cover:
Studies: 
→ Muscle Loss And Glp-1r Agonists Use
→ Weight Loss With Glp-1 Medicines Does Not Result In A Disproportionate Loss Of Muscle Mass Or Function In Obese Mice And HumansFurther Listening:
→ GLP-1s + Peptides Are Changing Fast, Here’s What You Need To Know
→ EP. 104: Fatty Liver 101 | Solo Episode
→ Orthopedic Medicine is a Scam PT. 3 | Osteoarthritis is Diabetes of the Joint
Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.