Millions of people worldwide have taken proton pump inhibitors (PPIs) since 1989 to manage gastroesophageal reflux disease (GERD) and other reflux disorders. These drugs have been heavily advertised, and many people today routinely take the “little purple pill” and similar medicines for months or even years at a time without getting a prescription, according to the U.S. Food and Drug Administration (FDA).

In this episode Dr. Amy discusses the studies done over the years that have raised questions about a number of serious and potentially life-threatening side effects.  Among other things, these pills have been tied to an increased risk of premature death, heart disease, certain cancers, dementia, lung disorders, fractures, kidney damage, pneumonia, and bacterial infections.