In this episode of The Digital Executive Podcast, host Brian Thomas sits down with Mandi Bateman, CEO and co-founder of Profile Health, to explore what happens when whole genome sequencing, longitudinal patient data, and clinical intelligence come together to give physicians a complete picture of who their patient really is. Mandi opens with hard-won lessons from her previous startups — most importantly, that precision medicine direct to consumer is a race to the bottom, and that the right path to scaling this kind of complex, data-heavy care is through the hands of physicians who have the training and trust to use it well. She explains why Profile Health deliberately chose the cash pay healthcare vertical as its beachhead: free from the constraints of insurance reimbursement, physicians in this space are already seeking advanced diagnostic tools, and patients are actively asking for them. The personal dimension runs deep — Mandi's own autoimmune disease was addressed through this kind of medicine, and her co-founder and chief science officer bring decades of clinical and molecular expertise that have made physician adoption remarkably smooth. On the trust question, she is direct: patients are not afraid of genomic testing — they want it — and the rare hesitation comes from fear of what they might find, not from privacy concerns. She closes with a vision of precision medicine at scale: whole genome sequencing as a one-time foundation, layered with wearables, biomarkers, and longitudinal data to enable truly preventative care that catches disease before it starts. Her conviction is that as sequencing costs continue to fall and consumers grow more engaged in their own health, the mainstream is closer than most people think — and the physicians who have the right tools will be the ones who lead the way there.If you liked what you heard today, please leave us a review - Apple or Spotify. Learn more about your ad choices. Visit megaphone.fm/adchoices